Results 51 to 60 of about 227,971 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Cyclic AMP signalling in pancreatic islets

open access: yes, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Nigel J. Pyne   +7 more
core   +1 more source

Constitutive expression of Vr-ERE gene in transformed grapevines confers enhanced resistance to eutypine, a toxin from Eutypa lata [PDF]

open access: yes, 2003
Eutypine (4-hydroxy-3-[3-methyl-3-butene-1-ynyl] benzaldehyde) is a toxin produced by Eutypa lata , the causal agent of eutypa dieback of grapevines.
Bouquet, Alain   +23 more
core   +1 more source

Cyclic liquefaction resistance of sand under a constant inflow rate

open access: yes, 2022
Cyclic resistance curves, derived through undrained element tests, are central to the study of liquefaction. Their use implies that water drainage is negligible during an earthquake.
Anastasopoulos, Ioannis   +1 more
core   +1 more source

Impact of Peracetic Acid on the Dynamic Cyclic Fatigue of Heat-Treated Nickel-Titanium Rotary Endodontic Instrument

open access: yesInternational Journal of Dentistry, 2021
Peracetic acid (PAA) is widely used as a sterilizing/disinfecting agent, and, in endodontics, it has been introduced as a promising irrigant in root canal treatment. It has been used at different concentrations to achieve various functions.
Suhad Jabbar Hamed Al-Nasrawi   +6 more
doaj   +1 more source

Cyclic Olefin Resist Polymers and Polymerizations for Improved Etch Resistance.

open access: yesJournal of Photopolymer Science and Technology, 1999
This paper will describe the strengths and unique challenges of building 193nm resists from acrylic polymers and cyclic olefin polymers. In particular, cyclic olefin (alternating) copolymer synthesis and properties will be discussed.
Allen, R. D.   +8 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of pumice content on the undrained cyclic behaviour of pumiceous soil

open access: yesSoils and Foundations
Pumice soil grains are characterized by their vesicular nature, which leads to lightweight, crushable grains with an extremely rough and angular surface texture.
Emma Gardiner   +4 more
doaj   +1 more source

Pullout behavior of polymeric strip in compacted dry granular soil under cyclic tensile load conditions

open access: yesJournal of Rock Mechanics and Geotechnical Engineering, 2018
Assessment of the reinforcement behavior of soil under cyclic and monotonic loads is of great importance in the safe design of mechanically stabilized earth walls. In this article, the method of conducting a multistage pullout (MSP) test on the polymeric
Sajad Razzazan   +2 more
doaj   +1 more source

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