Results 71 to 80 of about 208,622 (266)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The resistance ratchet: theoretical implications of cyclic selection pressure [PDF]
Journal of Antimicrobial Chemotherapy, 2005 To investigate the effects of cyclic antibiotic selection pressure on resistance in a simple mathematical model.The model assumed that resistance in microbial ecologies changes slowly with changing selection pressure, at a rate proportional to the difference between the current resistance level and the resistance level that would be in equilibrium with
openaire +2 more sources
Cyclic fatigue resistance of novel Genius and Edgefile nickel-titanium reciprocating instruments
Brazilian Oral Research, 2019 : This study aimed to assess the cyclic fatigue resistance of Genius and EdgeFile X1 reciprocating instruments compared with WaveOne Gold Primary. Twenty Genius (Ultradent) 25.04, 20 Genius 30.04, 20 EdgeFile X1 (EdgeEndo) and 20 WaveOne Gold Primary ...
Carlos Roberto Emerenciano Bueno +7 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
CYCLIC FATIGUE RESISTANCE OF HYFLEX EDM ROTARY FILES COMPARED TO M3 PRO GOLD AND MG3 BLUE ROTARY FILES (AN IN VITRO STUDY) [PDF]
Alexandria Dental JournalIntroduction: Despite the introduction of more durable files of various costs designed to minimize file separation and enhance the success rate of curved canal instrumentation.
Ali Buran, Raef Sherif, Ahmed Mobarak
doaj +1 more source
Teknika, 2020 Fenomena likuifaksi sering terjadi setelah kejadian gempa di beberapa tempat. Likuifaksi pada tanah dapat menyebabkan kerusakan yang parah bagi bangunan yang berada di atasnya, sehingga kerugian yang ditimbulkan sangat besar.
Enden Mina +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Effect of different torques in cyclic fatigue resistance of K3 rotary instruments
Brazilian Journal of Oral Sciences, 2015 Aim: To assess the effect of different torque values on cyclic fatigue resistance of K3 rotary nickeltitanium (NiTi) files. Methods: Eighty K3 files, size 25 mm, taper 0.04 were divided in 4 groups according to different torques (0.5, 1, 2 and 6 Ncm) and
Dirce Akemi Sacaguti Kawakami +4 more
doaj +1 more source