Results 101 to 110 of about 523,816 (270)

The cost of raising quantifiers

Glossa, 2018
The main proposal of this paper is that quantifier raising (QR) is not subject to QR-specific locality or domain restrictions but that differences observed between overt and covert movement are the result of an increased processing burden associated with
Susi Wurmbrand
doaj   +2 more sources

Controls on Erosion and Cyclic Step‐Formation Upstream of Waterfalls

Geophysical Research Letters
AbstractWaterfall retreat transmits base‐level perturbations upstream, thereby providing markers of changing climate and tectonics. In homogeneous rock, waterfalls often retreat either by direct waterfall‐face erosion or incision from repeating (‘cyclic’) steps formed above waterfalls. We lack knowledge on the conditions driving these different erosion
T. Inoue, Y. Hiramatsu, J. S. Scheingross, S. Yamaguchi, K. Takahashi   +4 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Electrochemical oxidation of quercetin in hydro-alcoholic solution

Journal of the Brazilian Chemical Society, 2006
The electrochemistry of quercetin hydro-alcoholic solutions of pH 2.2 to 9.2 was studied by cyclic voltammetry, controlled-potential electrolysis and UV-Vis spectroscopy.
Timbola Ana K., Souza Cristine D. de, Giacomelli Cristiano, Spinelli Almir   +3 more
doaj  

Protocol for conducting advanced cyclic tests in lithium-ion batteries to estimate capacity fade

STAR Protocols
Summary: Using advanced cyclic testing techniques improves accuracy in estimating capacity fade and incorporates real-world scenarios in battery cycle aging assessment.
Sai Krishna Mulpuri, Bikash Sah, Praveen Kumar   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Demonstration of laser speckle system on burner liner cyclic rig [PDF]

A demonstration test was conducted to apply speckle photogrammetry to the measurement of strains on a sample of combustor liner material in a cyclic fatigue rig.
Stetson, K. A.
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source