Results 81 to 90 of about 330,923 (308)

Cyclic creep behavior and life prediction of DZ125 alloy under different stress ratios

Journal of Physics: Conference Series
Abstract In order to study the creep behavior and mechanism of DZ125 alloy under cyclic creep under different stress ratios, cyclic creep experiments are performed under a temperature of 850°C and peak stress of 500 MPa, with stress ratios of 0.1, 0.3, 0.5, 0.7, 0.9, and 1, and the mechanical behavior and microstructure of creep samples ...
Haowen Chen, Xuming Niu, Zhigang Sun, Yingdong Song, Lu Zhang   +4 more
openaire   +1 more source

Cracking in asphalt materials [PDF]

, 2018
This chapter provides a comprehensive review of both laboratory characterization and modelling of bulk material fracture in asphalt mixtures. For the purpose of organization, this chapter is divided into a section on laboratory tests and a section on ...
AF Braham, Armelle Chabot, B Behnia, B Birgisson, B Delaporte, B Kim, BS Underwood, C Huet, D Bodin, D Bodin, Didier Bodin, DV Ramsamooj, Emmanuel Chailleux, Eshan V. Dave, Eshan V. Dave, Eshan V. Dave, F Dubois, F Dubois, F Dubois, F Jiang, GR Chehab, H Benedetto Di, H Benedetto Di, H Lemaistre, HJ Lee, HM Nguyen, J Mandel, JF Corte, JS Daniel, K Majidzadeh, Malcolm L. Williams, MJ Jacobs, MJ Lamborn, MP Wagoner, MP Wagoner, N Tapsoba, NH Gibson, R Roque, R Roque, R. A. Schapery, RA Schapery, RA Schapery, RA Schapery, S Ahmed, S Ahmed, S Ahmed, SH Song, Simon Pouget, SW Park, T Hou, Xinjun Li, YR Kim, YR Kim, YR Kim, YR Kim, Z Zhang, Z Zhang   +56 more
core   +5 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A contact problem aplication for the local behaviour of soil pile interaction [PDF]

, 2017
In geotechnical engineering, the main parameter for the performance of structures such as reinforced walls or deep foundations is often the shaft bearing capacity.
Baeßler, Matthias, Bronsert, Jeffrey, Dutto, Paola, Kullolli, Borana, Stutz, Henning   +4 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Shear-stress intensity factors for elastic sheets with cover plates [PDF]

Shear stress intensity factors are calculated for three problems concerning inextensible cover plates either bonded to or embedded in an elastic sheet which is under uniaxial tension.
Fichter, W. B.
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Cyclic debonding of unidirectional composite bonded to aluminum sheet for constant-amplitude loading [PDF]

Cyclic debonding rates were measured during constant-amplitude loading of specimens made of graphite/epoxy bonded to aluminum and S-glass/epoxy bonded to aluminum. Both room-temperature and elevated-temperature curing adhesives were used.
Crews, J. H., Jr., Everett, R. A., Jr., Roderick, G. L.   +2 more
core   +1 more source

Cyclic J integral using linear matching method [PDF]

, 2012
The extended version of the latest Linear Matching Method (LMM) has the capability to evaluate the stable cyclic response, which produces cyclic stresses, residual stresses and plastic strain ranges for the low cycle fatigue assessment with cyclic load ...
Chen, Haofeng, Chen, Weihang
core  

Cyclic behavior of a two-span RC beam built with plain reinforcing bars [PDF]

, 2011
Reinforced concrete structural elements lacking appropriate seismic detailing and built with plain reinforcing bars, and subjected to cyclic loads like the ones induced by earthquakes, are particularly sensitive to the bond-slip mechanism.
Costa, Aníbal, Fernandes, Catarina, Melo, José, Varum, Humberto   +3 more
core   +3 more sources