Results 251 to 260 of about 185,382 (296)
Cancer Science, EarlyView.Lysine acetyltransferase 2A (KAT2A) is a transcriptional coactivator and a member of the Histone Acetyltransferase (HAT) family. While altered KAT2A activity has been implicated in various cancers, its role in bladder cancer (BLCA) remains poorly understood.
Wenjie Yang +8 more
wiley +1 more source
Cyclin-Dependent Kinase 5 and Insulin Secretion
, 2008 Cyclin-dependent kinase 5 (Cdk5) is emerging as a multifunctional kinase involved in regulating numerous cellular processes. Lately, Cdk5 has also emerged as a key controller of regulated membrane fusion in secretory cells. The pancreatic β-cell is highly specialized to secrete insulin in response to elevated glucose concentrations in the blood.
Christina Bark +4 more
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A brain-specific activator of cyclin-dependent kinase 5
Nature, 1994 Phosphorylation of the neurofilament proteins of high and medium relative molecular mass, as well as of the Alzheimer's tau protein, is thought to be catalysed by a protein kinase with Cdc2-like substrate specificity. We have purified a novel Cdc2-like kinase from bovine brain capable of phosphorylating both the neurofilament proteins and tau.
Lew, J. +6 more
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Cyclin-Dependent Kinase 5 in Axon Growth and Regeneration
, 2012 Injury to the central nervous system often leads to irreversible deficits because of the failure of damaged axons to regrow and restore the functional neural circuitry. Coordinated orchestration of multiple cellular processes including cytoskeletal dynamics and gene expression are essential for both developmental and regenerative axon growth. Recently,
Ye, Tao LIFS, Fu, Kit Yu, Ip, Nancy Y.
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Extraneuronal roles of cyclin‐dependent kinase 5
BioEssays, 2006AbstractCyclin‐dependent kinase 5 (Cdk5) is recognized as an essential molecule in the brain, where it regulates several neuronal activities, including cytoskeletal remodeling and synaptic transmission. While activity of Cdk5 has primarily been associated with neurons, there are now substantial data indicating that the kinase's activity and function ...
Jesusa L, Rosales, Ki-Young, Lee
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Acetylation of cyclin-dependent kinase 5 is mediated by GCN5
Biochemical and Biophysical Research Communications, 2014Cyclin-dependent kinase 5 (CDK5), a member of atypical serine/threonine cyclin-dependent kinase family, plays a crucial role in pathophysiology of neurodegenerative disorders. Its kinase activity and substrate specificity are regulated by several independent pathways including binding with its activator, phosphorylation and S-nitrosylation.
Juhyung, Lee +5 more
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The Activation and Inhibition of Cyclin-Dependent Kinase-5 by Phosphorylation
Biochemistry, 2007Despite the very similar 3-dimensional structures as reflected by the more than 60% identity in amino acid sequences, CDK2 and CDK5 have very different functions and characteristics. Phosphorylation on a conserved Thr14 can inhibit activities of both the kinases, but phosphorylating another conserved Tyr15, however, can lead to totally opposite ...
Zhang, B. +3 more
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Cyclin-dependent Kinase 5 and Neurodegenerative Diseases
Molecular NeurobiologyNeurodegenerative diseases are a group of diseases characterized by the progressive loss of neurons, including Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis. These diseases have a high incidence and mortality rate globally, placing a heavy burden on patients and their families.
Mingxue Song +3 more
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