Results 301 to 310 of about 338,209 (343)
Some of the next articles are maybe not open access.
Cyclin-Dependent Kinase 5--A Neuronal Killer?
Science of Aging Knowledge Environment, 2003In dividing cells, cyclin-dependent kinases (Cdks) are cell cycle-associated protein kinases that regulate proliferation, differentiation, senescence, and apoptosis. In neurons that no longer divide, deregulation of Cdks, especially Cdk5, occurs in many neurological disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD).
openaire +2 more sources
Cyclin-dependent Kinase 5 and Neurodegenerative Diseases
Molecular NeurobiologyNeurodegenerative diseases are a group of diseases characterized by the progressive loss of neurons, including Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis. These diseases have a high incidence and mortality rate globally, placing a heavy burden on patients and their families.
Mingxue Song +3 more
openaire +2 more sources
Cyclin-dependent kinases 5 template: Useful for virtual screening
Computers in Biology and Medicine, 2012The present study reports the development of a template for the active binding site of Cdk5 for structure-based drug design. The developed template of Cdk5 was validated by redocking with ligands I (PBD code 1UNG), II (PBD code 1UNL) and III (PBD code 1UNH).
Siripit, Pitchuanchom +4 more
openaire +2 more sources
Targeting Cyclin-Dependent Kinase 5 (CDK5) in Glioblastoma
2021Glioblastoma multiforme (GBM) is the most common brain cancer that develops from the malignant transformation of astrocytes and glial cells. The majority of their tumors occur due to dysregulation of cell cycle related-genes like cyclin-dependent kinases that promote uncontrollable cell proliferation and survival.
Rusia H. Lee +2 more
openaire +1 more source
Modulation of Reelin signaling by Cyclin-dependent kinase 5
Brain Research, 2007The Reelin signaling and Cyclin-dependent kinase 5 (Cdk5) both regulate neuronal positioning in the developing brain. Using double-transgenic mice, we have previously shown that these two signaling pathways lie in parallel fashion and have a genetic interaction.
Toshio, Ohshima +4 more
openaire +2 more sources
Cyclin-dependent kinase 5 (CDK5) and neuronal cell death
Cell and Tissue Research, 2003Many neurological disorders like Parkinson's and Alzheimer's disease, amyotrophic lateral sclerosis (ALS) or stroke have in common a definite loss of CNS neurons due to apoptotic or necrotic neuronal cell death. Previous studies suggested that proapoptotic stimuli may trigger an abortive and, therefore, eventually fatal cell cycle reentry in ...
J H, Weishaupt, C, Neusch, M, Bähr
openaire +2 more sources
Cyclin-Dependent Kinase 5 in Axon Growth and Regeneration
2012Injury to the central nervous system often leads to irreversible deficits because of the failure of damaged axons to regrow and restore the functional neural circuitry. Coordinated orchestration of multiple cellular processes including cytoskeletal dynamics and gene expression are essential for both developmental and regenerative axon growth. Recently,
Ye, Tao LIFS, Fu, Kit Yu, Ip, Nancy Y.
openaire +3 more sources
Cyclin-Dependent Kinase 5 and Insulin Secretion
2008Cyclin-dependent kinase 5 (Cdk5) is emerging as a multifunctional kinase involved in regulating numerous cellular processes. Lately, Cdk5 has also emerged as a key controller of regulated membrane fusion in secretory cells. The pancreatic β-cell is highly specialized to secrete insulin in response to elevated glucose concentrations in the blood.
Christina Bark +4 more
openaire +1 more source
Role of cyclin-dependent kinase 5 in capsaicin-induced cough
European Journal of Pharmacology, 2007The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice. Pretreatment with inhaled roscovitine, a selective Cdk5 inhibitor, at concentrations of 0.3 to 3 mM inhibited the number of capsaicin-induced coughs in a concentration-dependent manner.
Junzo, Kamei +3 more
openaire +2 more sources
Acetylation of cyclin-dependent kinase 5 is mediated by GCN5
Biochemical and Biophysical Research Communications, 2014Cyclin-dependent kinase 5 (CDK5), a member of atypical serine/threonine cyclin-dependent kinase family, plays a crucial role in pathophysiology of neurodegenerative disorders. Its kinase activity and substrate specificity are regulated by several independent pathways including binding with its activator, phosphorylation and S-nitrosylation.
Juhyung, Lee +5 more
openaire +2 more sources