Results 311 to 320 of about 338,209 (343)

Reelin and Cyclin-Dependent Kinase 5

2008
Reelin, an extracellular signaling molecule, and cyclin-dependent kinase 5 (Cdk5), a cytoplasmic kinase, are key regulators of normal brain development, including establishment of the complex brain structure. Recent studies have indicated that both Reelin signaling and Cdk5 are also involved in synaptic plasticity and neurodegeneration. In this chapter,
openaire   +1 more source

Cyclin-dependent kinase-5 (CDK5) and amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 2000
Cyclin-dependent kinase-5 (CDK5) is a serine-threonine protein kinase that has been implicated in a number of physiological processes in nerve and muscle cells, including neurogenesis, neuritic outgrowth, axonal transport of membrane-bound organelles and myogenesis.
openaire   +2 more sources

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

Nature, 1994
L. Tsai, I. Delalle, V. Caviness, Teresa Chae, E. Harlow   +4 more
semanticscholar   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Targeting cyclin dependent kinase 5 in hepatocellular carcinoma

2014
For a long time cyclin dependent kinase 5 (Cdk5) was thought to be of exclusive importance in neuronal cells. However, recently increasing evidence suggests a function of Cdk5 in cancer progression. In the present study, we examined the role of Cdk5 in hepatocellular carcinoma (HCC), a highly chemoresistant cancer with poor prognosis.
openaire   +1 more source

Cyclin dependent kinase 5: A novel avenue for Alzheimer's disease.

Brain Research Bulletin, 2017
Anisha S. Bhounsule, L. Bhatt, K. Prabhavalkar, Manisha Oza   +3 more
semanticscholar   +1 more source

Cyclin-Dependent Kinase 5

2009
T. Ohshima, K. Mikoshiba
openaire   +1 more source

Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia.

Experimental Neurology, 2015
Jiao Liu, Jun-hui Du, Yanrui Yang, Yun Wang   +3 more
semanticscholar   +1 more source

Cyclin Dependent Kinase 5 (CDK5) and Neurodegeneration

Clinical Science, 1999
N Bajaj, AL S-Sarraj, PN Leigh, CCJ Miller   +3 more
openaire   +1 more source

Steered Molecular Dynamics Simulations for Studying Protein-Ligand Interaction in Cyclin-Dependent Kinase 5

Journal of Chemical Information and Modeling, 2014
J. S. Patel, Anna Berteotti, S. Ronsisvalle, W. Rocchia, A. Cavalli   +4 more
semanticscholar   +1 more source