Results 71 to 80 of about 435,825 (269)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Coordination cycles [PDF]

Games and Economic Behavior, 2005
Players repeatedly face a coordination problem in a dynamic global game. By choosing a risky action (invest) instead of waiting, players risk instantaneous losses as well as a loss of payoffs from future stages, in which they cannot participate if they go bankrupt.
openaire   +6 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Volcanically driven Hg–C–S cycling and climate change across the Early Permian Artinskian warming

Communications Earth & Environment
Climate change and driving mechanisms of the Late Paleozoic Ice Age, an ideal analogue to the present-day global change, remain controversial. Here we propose a volcanic carbon–sulfur radiative forcing mechanism by investigating the Lower Permian ...
Anbin Wu, Jian Cao, Jingkun Zhang, Wenxuan Hu, Yuce Wang, Chenjia Zhang, Wenjun He   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Isolation of Cycles

Graphs and Combinatorics, 2020
For any graph $G$, let $ι_{\rm c}(G)$ denote the size of a smallest set $D$ of vertices of $G$ such that the graph obtained from $G$ by deleting the closed neighbourhood of $D$ contains no cycle. We prove that if $G$ is a connected $n$-vertex graph that is not a triangle, then $ι_{\rm c}(G) \leq n/4$. We also show that the bound is sharp. Consequently,
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Solvent engineering for scalable fabrication of perovskite/silicon tandem solar cells in air

Nature Communications
Perovskite/silicon tandem solar cells hold great promise for realizing high power conversion efficiency at low cost. However, achieving scalable fabrication of wide-bandgap perovskite (~1.68 eV) in air, without the protective environment of an inert ...
Xuntian Zheng, Wenchi Kong, Jin Wen, Jiajia Hong, Haowen Luo, Rui Xia, Zilong Huang, Xin Luo, Zhou Liu, Hongjiang Li, Hongfei Sun, Yurui Wang, Chenshuaiyu Liu, Pu Wu, Han Gao, Manya Li, Anh Dinh Bui, Yi Mo, Xueling Zhang, Guangtao Yang, Yifeng Chen, Zhiqiang Feng, Hieu T. Nguyen, Renxing Lin, Ludong Li, Jifan Gao, Hairen Tan   +26 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Build it and they will come? The effects of a new infrastructure on cycling practices and experiences

Transportation Research Interdisciplinary Perspectives
What are the effects of cycling infrastructure? This question is crucial as cities begin to give more space to cycling. In this paper, we propose to use the theoretical concept of affordance to consider not only what a cycle lane affords (or enables ...
Patrick Rérat, Aurélie Schmassmann
doaj   +1 more source