Results 91 to 100 of about 150,508 (257)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Boosting Cycling Stability of Polymer Sodium Battery by “Rigid-Flexible” Coupled Interfacial Stress Modulation [PDF]
, 2022 The discontinuous interfacial contact of solid-state polymer metal batteries is due to the stress changes in the electrode structure during cycling, resulting in poor ion transport. Herein, a rigid-flexible coupled interface stress modulation strategy is
Xiangli Che (3745582) +10 more
core
Improved Cycling Stability of Cobalt-free Li-rich Oxides with a Stable Interface by Dual Doping [PDF]
, 2016 Li-rich cobalt-free oxides, popularly used as a cathode with high capacity in lithium ion battery, always suffer from poor cycling stability between 2.0 and 4.8 V vs Li+/Li, especially when cycled at high temperatures (>50 °C). To overcome this issue, Na+
Fu, Chaochao +5 more
core +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
A comprehensive review on preparation, dispersion stability and phase change cycling stability of phase change microemulsions [PDF]
Phase change material emulsions (PCMEs), as novel latent heat storage media, have great potential to advance applications. A comprehensive review of PCMEs is provided in this paper, including preparation methods, dispersion stability, phase change ...
Yu, Y. +5 more
core
Effects of thermal cycling and thermal stability on 2G HTS pancake coils [PDF]
, 2015 Degradation of superconducting critical currents of 2G-HTS coils may appear upon thermal cycling due to the tensile stress differences of its elements that induce increasing tape damages.
Martínez Fernández, Elena +6 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source