Results 91 to 100 of about 42,214 (296)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Can Automated Vehicles Improve Cyclist Safety in Urban Areas?

Safety, 2019
Automated vehicles (AVs) are expected to assist in decreasing road traffic fatalities, particularly among passenger cars. However, until now limited research has been conducted on how they will impact the safety of vulnerable road users (VRUs) (i.e ...
Pavlos Tafidis, Ali Pirdavani, Tom Brijs, Haneen Farah   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Cyclists in shared bus lanes: could there be unrecognised impacts on bus journey times? [PDF]

, 2019
This paper contributes to debates around improving the modelling of cycles, through an exploratory case study of bus–cycle interactions in London. This case study examines undocumented delays to buses caused by high volumes of cyclists in bus lanes.
Luke Best, Jones, P., Aldred, R., Rachel Aldred, Phil Jones, Best, L.   +5 more
core   +1 more source

Hyperpronation in Cyclists

Journal of Science and Cycling, 2023
Even with the best bike positioning, overuse injuries to the lower extremities may still occur. Over time, due to repetitious pedaling, even the slightest deviation in skeletal alignment or biomechanics may result in injury, dysfunction or reduced performance.
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Comparative effects of foam roller and cross frictional massage on Iliotibial band syndrome in cyclist

Journal Riphah College of Rehabilitation Sciences
Background: lliotibial band syndrome is a friction syndrome, it is a common dysfunction in cyclists and runner. Manual pressure or even spontaneously pressure on iliotibial band can produce pain which may be localized or referred.
Mudassar Ilyas, Muzna Munir, Anam Bint Irfan, Nabira Izhar   +3 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Effect of the Rotor crank system on cycling performance [PDF]

, 2009
The aim of this study was to evaluate the impact of a novel crank system on laboratory time-trial cycling performance. The Rotor system makes each pedal independent from the other so that the cranks are no longer fixed at 180 degrees.
Coleman, Damian A, Galbraith, Andy, Hopker, James, Jobson, Simon A., Galbraith, Andrew, Nevill, Alan M., Coleman, Damian A., Hopker, James G.   +7 more
core   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source