Results 101 to 110 of about 42,214 (296)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Ultrasonographic Evaluation of the Patellar Tendon in Cyclists, Volleyball Players, and Non-Practitioners of Sports—The Influence of Gender, Age, Height, Dominant Limb, and Level of Physical Activity

Journal of Functional Morphology and Kinesiology
This study was based on the ultrasound evaluation of the patellar tendon dimensions in the anteroposterior and transversal approaches in sports practitioners (cyclists and volleyball players) and non-sports practitioners.
Ângela Pissarra, Luís Ribeiro, Sónia Rodrigues   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Maximal and sub-maximal exercise tests alter PBMC microRNA expression: insights into sport- and sex-specific variations

Frontiers in Physiology
IntroductionStudying microRNAs in the immune cells of athletes offers a novel perspective on the molecular regulation of immune function and recovery, potentially uncovering strategies to enhance performance and resilience to physical stress.
Guy Shalmon, Guy Shalmon, Guy Shapira, Guy Shapira, Rawan Ibrahim, Ifat Israel-Elgali, Meitar Grad, Rani Shlayem, Ilan Youngster, Ilan Youngster, Mickey Scheinowitz, Mickey Scheinowitz, Noam Shomron, Noam Shomron   +13 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Muscle typology of world-class cyclists across various disciplines and events

, 2020
Purpose. Classical track-and-field studies demonstrated that elite endurance athletes exhibit a slow muscle typology, while elite sprint athletes have a predominant fast muscle typology.
Jan Vancompernolle, Lievens, Eline, Eline Lievens, Tine Bex, Kim Van Vossel, Bellinger, Phillip, Phillip Bellinger, Van Vossel, Kim, Derave, Wim, Vancompernolle, Jan, Bex, Tine, Minahan, Clare, Clare Minahan, Wim Derave   +13 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Wales 1910

, 1910
Relief shown by contours, gradient tints and spot heights.; "Reduced by permission from the New Revised Ordnance Survey, with special local revision and correction to date of publication."; "Roads revised by the Cyclists' Touring Club."Color;1:126 ...

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