Results 121 to 130 of about 42,214 (296)

Epidemiology of cycling road injuries-related deaths

Emergency Care Journal
Dear Editor,   There are now several lines of evidence that millions of people around the world use bicycles as a routine means of transportation. In the US alone, for example, the website Statista estimates that 55 million people use bicycles as a ...
Camilla Mattiuzzi, Giuseppe Lippi
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Potential factors associated with knee pain in cyclists: a systematic review

, 2018
Rodrigo Rico Bini, Alice Flores Bini La Trobe Rural Health School, La Trobe University, Flora Hill Campus, Bendigo, VIC, Australia Abstract: The potential factors associated with overuse injuries and pain in cyclists that are supported by evidence remain
Flores Bini A, Bini RR
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Gut microbiota composition correlates with PBMC microRNA expression following maximal exercise testing in endurance athletes

Frontiers in Microbiomes
IntroductionMicroRNAs (miRNAs) are key post-transcriptional regulators that also take part in immune responses and recovery processes following exercise.
Guy Shalmon, Guy Shalmon, Guy Shapira, Guy Shapira, Rawan Ibrahim, Ifat Israel-Elgali, Meitar Grad, Rani Shlayem, Ilan Youngster, Ilan Youngster, Mickey Scheinowitz, Mickey Scheinowitz, Noam Shomron, Noam Shomron   +13 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Characteristics of cyclists and non-cyclists.

, 2019
Characteristics of cyclists and non-cyclists.
Juha M. Hijmans (5855786), Chiraphan Puttipaisan (7124537), Jan H. B. Geertzen (311144), Rienk Dekker (393389), Pensupa Pimchan (7124543), Pieter U. Dijkstra (311146), Chanapak Dismanopnarong (7124534), Jutamanee Poonsiri (5961842), Samai Suakonburi (7124540), Yasmin Nutchamlong (7124531)   +9 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Tropaeum Traiani Monument. A Multi-Channel Strategy for Sustainable Development of the Territory through Cycle Tourism

Styles of Communication, 2018
The article explores the methodological approach of the designer around the promotion and communication project of the Tropaeum Traiani and the municipality of Adamclisi, located in the Dobruja region in Romania.
Anca Serbanescu
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source