Results 131 to 140 of about 42,214 (296)
Den här rapporten relaterar till en del av det uppdrag av regeringen som Transportstyrelsen fick hösten 2021: att analysera och vid behov lämna förslag till hur ändrade trafikregler kan främja säker omkörning av cyklister.
Niska, Anna,, Kircher, Katja,
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Journal of the Royal College of Physicians of London, 1989 H, Williams, J, Brett, A, du Vivier
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Surveillance of Racing Cyclists in Training: A Bourdieusian Perspective
, 2013 Research into the complexities of social identity construction and maintenance within racing cycling cultures has been neglected in sport sociology and studies of cycling group interactions are lacking.
Gibbons, Tom +2 more
core +1 more source
Avaliação da técnica de pedalada de ciclistas em diferentes alturas do selim [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Desportos. Programa de Pós-Graduação em Educação FísicaIntrodução: A biomecânica do ciclismo estuda os fatores ambientais e os fatores mecânicos internos e externos que podem ...
Moro, Vanderson Luis
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source