Results 181 to 190 of about 121,287 (309)

Convergent Total Synthesis of (-)-Methyl Gummiferolate Enabled by Pattern Recognition and Radical Cyclization. [PDF]

J Am Chem Soc
Zhao W, Zhen J, Dai M.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Boron trifluoride-mediated domino dehydration/electrophilic cyclization of alkynols: mechanistic insights and origin of stereoselectivity. [PDF]

RSC Adv
Okitsu T, Yoshikawa T, Takayori Y, Hirata S, Shinoki M, Ito M, Sakata K, Hatano M.   +7 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Sortase-mediated generation of various macrocyclic peptide scaffolds from low-reactivity electrophilic substrates. [PDF]

Chem Sci
Xia ZM, Wei HM, Xue JH, Sun YN, Wan XC, Tong HR, Zhou L, Shi P, Fang GM, Tian C.   +9 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Recent Advances in Synthetic Strategies and Medicinal Properties of Thienopyridines. [PDF]

Int J Mol Sci
Ermolaeva A, Baykova S, Baykov S, Ivanov R, Minskaia E.   +4 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

One-pot divergent synthesis of 5-arylmethyl oxazoles and polyacenes from propargylic amides and arynes.

Org Chem Front
Werling AYR, Yang Y, Jones CR.
europepmc   +1 more source

Catalytic Ring Opening of Epoxides by Metal Triflates: Influence of a Pending Olefin. [PDF]

Molecules
Jorandon M, Patino N, Duñach E, Mehiri M.   +3 more
europepmc   +1 more source