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Nickel-Catalyzed Ligand-Controlled Selective Reductive Cyclization/Cross-Couplings.

Accounts of Chemical Research, 2023
ConspectusThe use of quaternary stereocenters during lead candidate optimization continues to grow because of improved physiochemical and pharmacokinetic profiles of compounds with higher sp3 fraction.
Qi Pan, Yu Ping, Wangqing Kong
semanticscholar   +1 more source

New Twists in Nazarov Cyclization Chemistry.

Accounts of Chemical Research, 2020
ConspectusThe defining feature of the Nazarov cyclization is a 4π-conrotatory electrocyclization, resulting in the stereospecific formation of functionalized cyclopentanones.
A. Frontier, Jackson J Hernandez
semanticscholar   +1 more source

Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by Merging C-H Activation and Nucleophilic Cyclization.

Journal of the American Chemical Society, 2019
Enantiomeric access to pentatomic biaryls is challenging due to their relatively low rotational barrier. Reported herein is the mild and highly enantioselective synthesis of 2,3'-biindolyls via underexplored integration of C-H activation and alkyne ...
Miaomiao Tian   +4 more
semanticscholar   +1 more source

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