Results 61 to 70 of about 2,874,801 (150)

Functionalized 4-Hydroxy Coumarins: Novel Synthesis, Crystal Structure and DFT Calculations

Molecules, 2011
A novel short-step methodology for the synthesis in good yields of functionalized coumarins has been developed starting from an activated precursor, the N-hydroxysuccinimide ester of O-acetylsalicylic acid.
Olga Igglessi-Markopoulou, Vickie McKee, John Markopoulos, Valentina Stefanou, Antreas Afantitis, Giorgos Athanasellis, Georgia Melagraki, Dimitris Matiadis   +7 more
doaj   +1 more source

SpyTag/SpyCatcher cyclization confers resilience to boiling on a mesophilic enzyme.

Angewandte Chemie, 2014
SpyTag is a peptide that spontaneously forms an amide bond with its protein partner SpyCatcher. SpyTag was fused at the N terminus of β-lactamase and SpyCatcher at the C terminus so that the partners could react to lock together the termini of the enzyme.
C. Schoene, J. Fierer, S. Bennett, M. Howarth   +3 more
semanticscholar   +1 more source

AgOTf-catalyzed one-pot reactions of 2-alkynylbenzaldoximes with α,β-unsaturated carbonyl compounds

Beilstein Journal of Organic Chemistry, 2013
AgOTf-catalyzed one-pot reactions of 2-alkynylbenzaldoximes with various α,β-unsaturated carbonyl compounds under mild conditions are described, which provides a facile and efficient pathway for the synthesis of 1-alkylated isoquinoline derivatives.
Qiuping Ding, Dan Wang, Puying Luo, Meiling Liu, Shouzhi Pu, Liyun Zhou   +5 more
doaj   +1 more source

Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids

Molecules, 2015
This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Clément Paris, Omar Brun, Enrique Pedroso, Anna Grandas   +3 more
doaj   +1 more source

A reagent-free, sequence-dependent in situ peptide self-cyclization strategy under physiological condition

European Journal of Medicinal Chemistry Reports
Cyclic peptides are an important class of bioactive molecules used as drugs as well as biomolecular probes. Peptide cyclization under the physiological environment, without added chemicals or reagents, would be a highly useful technique for in situ ...
Nibedita Ghosh, Lal Mohan Kundu
doaj  

A one-pot multistep cyclization yielding thiadiazoloimidazole derivatives

Beilstein Journal of Organic Chemistry, 2014
A versatile synthetic procedure is described to prepare the benzimidazole-fused 1,2,4-thiadiazoles 2a–c via a methanesulfonyl chloride initiated multistep cyclization involving the intramolecular reaction of an in-situ generated carbodiimide with a ...
Debabrata Samanta, Anup Rana, Jan W. Bats, Michael Schmittel   +3 more
doaj   +1 more source

“Plasmalogen-type” cyclic acetals: formation and conformation of the 1,3-dioxanes and 1,3-dioxolanes from 1-O-cis-alk-1′-enyl-sn-glycerols

Journal of Lipid Research, 1972
Acid-catalyzed cyclization of 1-O-cis-alk-1′-enyl-sn-glycerol produced four structurally and geometrically isomeric long-chain cyclic acetals of glycerol.
W.J. Baumann, T.H. Madson, B.J. Weseman
doaj  

Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis

Nature Chemical Biology, 2018
Benjamin R. Lichman, M. Kamileen, G. Titchiner, G. Saalbach, Clare E. M. Stevenson, D. Lawson, S. O’Connor   +6 more
semanticscholar   +1 more source

Helicity-Dependent Enzymatic Peptide Cyclization. [PDF]

J Pept Sci
Durukan C, Faierson J, van der Wal I, Pérez JL, Hennig S, Grossmann TN.   +5 more
europepmc   +1 more source

Enantioselective cyclizations and cyclization cascades of samarium ketyl radicals

Nature Chemistry, 2017
Nicolas Kern, Mateusz P. Plesniak, J. McDouall, D. Procter   +3 more
semanticscholar   +1 more source