Results 61 to 70 of about 797,239 (340)
Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt
Beilstein Journal of Organic Chemistry, 2020 A synthesis of fluorinated pyrimidines under mild conditions from amidine hydrochlorides and the recently described potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained.
Tobias Lucas +2 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Cationic Cyclization Involving a Remote Allene Function in the Trifluoroethanolysis of Hepta-5,6-dienyl Toluene-p-sulphonate [PDF]
, 1973 The remote allene function participates efficiently in the trifluoroethanolysis of hepta-5,6-dienyl toluene-p-sulphonate, leading to the cyclized 2-methylenecyclohexyl ...
Bergman, Robert G. +2 more
core
Exact theory of kinkable elastic polymers [PDF]
, 2004 The importance of nonlinearities in material constitutive relations has long been appreciated in the continuum mechanics of macroscopic rods. Although the moment (torque) response to bending is almost universally linear for small deflection angles, many ...
A. Y. Grosberg +14 more
core +5 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Effects of Sequence Disorder on DNA Looping and Cyclization
, 2007 Effects of sequence disorder on looping and cyclization of the double-stranded DNA are studied theoretically. Both random intrinsic curvature and inhomogeneous bending rigidity are found to result in a remarkably wide distribution of cyclization ...
Alexei V. Tkachenko +5 more
core +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Synthesis of vinyldihydropyran by cooperative catalysis [PDF]
Journal of the Serbian Chemical Society, 2016 5-Unsaturated aldehydes with a suitably positioned allylic halide, or phosphate, leaving group undergo doubly-catalyzed cyclization to give dihydropyran derivatives.
Vulović Bojan +3 more
doaj +1 more source
J-factors of short DNA molecules
, 2016 The propensity of short DNA sequences to convert to the circular form is studied by a mesoscopic Hamiltonian method which incorporates both the bending of the molecule axis and the intrinsic twist of the DNA strands.
Bates A. D. +4 more
core +1 more source
The effect of host structure on the selectivity and mechanism of supramolecular catalysis of Prins cyclizations. [PDF]
, 2015 The effect of host structure on the selectivity and mechanism of intramolecular Prins reactions is evaluated using K12Ga4L6 tetrahedral catalysts. The host structure was varied by modifying the structure of the chelating moieties and the size of the ...
Bergman, Robert G +8 more
core +2 more sources