Results 301 to 310 of about 221,688 (338)

N-actylcysteine inhibits diethyl phthalate-induced inflammation via JNK and STAT pathway in RAW264.7 macrophages. [PDF]

BMC Mol Cell Biol
Kim JH, Lee JH, Koo YJ, Song JW.
europepmc   +1 more source

The effect of aspirin on aneurysm wall enhancement: A study in rabbits and humans.

Interv Neuroradiol
Sagues E, Ojeda D, Gudino A, Dier C, Shenoy N, Saleem A, Kadiervel R, Sanchez S, Torres MB, Lehman VT, Hasan D, Samaniego EA.   +11 more
europepmc   +1 more source

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in the human prostate [PDF]

Urology, 2000
To determine the cell-specific expression of the two major isoforms of cyclooxygenase (COX-1 and COX-2) in human noncancerous and cancerous prostatic tissues.Thirty-one specimens of prostate carcinoma (CaP) and 10 specimens of benign prostatic hyperplasia (BPH) were stained with mouse antihuman COX-1 and COX-2 monoclonal antibodies.
Pamela D. Unger, Adam P. Klausner, Xin-Hua Liu, Alice C. Levine, Alexander Kirschenbaum, Richard Lee, Shen Yao   +6 more
openaire   +2 more sources

Cyclooxygenase and Colon Cancer [PDF]

Prostaglandins & Other Lipid Mediators, 2001
There is considerable interest in the involvement of cyclooxygenase-2 (COX-2) in colon carcinogenesis and its progression, because nonsteroidal anti-inflammatory drugs (NSAIDs) reduce mortality from colon cancer and COX-2 is one of the known targets of NSAIDs. COX-2 mRNA and protein levels are increased in colon cancer tissues from patients and in some
Shingo Tsuji, Sunao Kawano, Masahiko Tsujii   +2 more
openaire   +3 more sources

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Cyclooxygenase‐independent actions of cyclooxygenase inhibitors

The FASEB Journal, 2001
Several studies have demonstrated unequivocally that certain nonsteroidal anti-inflammatory drugs (NSAIDs) such as sodium salicylate, sulindac, ibuprofen, and flurbiprofen cause anti-inflammatory and antiproliferative effects independent of cyclooxygenase activity and prostaglandin synthesis inhibition.
Gerd Geisslinger, Josef Pfeilschifter, Irmgard Tegeder   +2 more
openaire   +3 more sources

Pharmacogenomics of Cyclooxygenases

Pharmacogenomics, 2015
Cyclooxygenases (COX-1 and COX-2) are key enzymes in several physiopathological processes. Many adverse drugs reactions to NSAIDs are attributable to COX-inhibition. The genes coding for these enzymes (PTGS1 and PTGS2) are highly variable, and variations in these genes may underlie the risk of developing, or the clinical evolution of, several diseases ...
José A. G. Agúndez, Miguel Blanca, Jose A. Cornejo-Garcia, Elena García-Martín   +3 more
openaire   +3 more sources