Results 321 to 330 of about 221,688 (338)
Some of the next articles are maybe not open access.
Role of Cyclooxygenases in Angiogenesis
Current Medicinal Chemistry, 2000Angiogenesis is the process by which new blood vessels are formed. This process supports normal physiology as well as contributes to progression of disease. Progressive rheumatoid arthritis and growth of tumors are two pathologies to which angiogenesis contributes.
Jaime L. Masferrer +2 more
openaire +3 more sources
Annual Review of Pharmacology and Toxicology, 1998
▪ Abstract Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several laboratories identified a product from a second gene with COX activity and called it COX-2.
Y. S. Bakhle +2 more
openaire +3 more sources
▪ Abstract Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several laboratories identified a product from a second gene with COX activity and called it COX-2.
Y. S. Bakhle +2 more
openaire +3 more sources
Co‐Oxidation by Cyclooxygenases
Current Protocols in Toxicology, 2009AbstractCyclooxygenases (COXs; prostaglandin H2synthases) catalyze the bis‐dioxygenation of arachidonic acid (AA) to generate prostaglandin (PG) G2followed by the peroxidative cleavage of PGG2to yield PGH2, the precursor to all of the vasoactive PGs. These enzymes utilize a Fe‐protoporhyrin IX (heme) co‐factor to catalyze peroxide bond cleavage, which ...
Trevor M. Penning, Lawrence M. Szewczuk
openaire +3 more sources
Veterinary and Comparative Oncology, 2004
AbstractProstatic carcinoma occurs primarily in older castrated male dogs and is typically a fatal disease (most dogs die within few months after the initial diagnosis). Surgery, i.e., total prostatectomy, or radiation therapy is often not pursued due to risks of complications and a high rate of distant metastasis.
Karin U. Sorenmo +4 more
openaire +3 more sources
AbstractProstatic carcinoma occurs primarily in older castrated male dogs and is typically a fatal disease (most dogs die within few months after the initial diagnosis). Surgery, i.e., total prostatectomy, or radiation therapy is often not pursued due to risks of complications and a high rate of distant metastasis.
Karin U. Sorenmo +4 more
openaire +3 more sources
Cyclooxygenase isoforms and atherosclerosis
Expert Reviews in Molecular Medicine, 2003Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of arthritis and pain. However, their long-term use is limited by gastrointestinal (GI) side effects such as gastric ulcers. NSAIDs act by inhibiting an enzyme called cyclooxygenase. Cyclooxygenase (COX) catalyses the generation of prostaglandins from arachidonic acid.
Desmond J. Fitzgerald, Orina Belton
openaire +2 more sources
Cyclooxygenase 2 and the kidney
Current Opinion in Nephrology and Hypertension, 2001Cyclooxygenase metabolizes arachidonic acid to a family of bioactive fatty acids designated prostaglandins. Two isoforms of cyclooxygenase exist, designated COX1 and COX2. These isoforms are expressed in distinct but important areas of the kidney. COX1 predominates in vascular smooth muscle and collecting ducts, whereas COX2 predominates in the macula ...
Raymond C. Harris, Matthew D. Breyer
openaire +3 more sources
Cyclooxygenase Inhibition and Atherothrombosis
Current Drug Targets, 2006Cyclooxygenases represent a major target of pharmaceutical therapy. Cyclooxygenase inhibitors are applied in order to reduce inflammation, to relieve from pain, or to prevent atherothrombotic complications in cardiovascular disease. Inhibition of platelet aggregation by aspirin, which is due to inhibition of platelet cyclooxygenase-dependent formation ...
Florian Krötz, Hae-Young Sohn
openaire +3 more sources
The Structure of Mammalian Cyclooxygenases
Annual Review of Biophysics and Biomolecular Structure, 2003▪ Abstract Cyclooxygenases-1 and -2 (COX-1 and COX-2, also known as prostaglandin H2synthases-1 and -2) catalyze the committed step in prostaglandin synthesis. COX-1 and -2 are of particular interest because they are the major targets of nonsteroidal antiinflammatory drugs (NSAIDs) including aspirin, ibuprofen, and the new COX-2-selective inhibitors ...
Anne M. Mulichak, R. Michael Garavito
openaire +3 more sources
Cyclooxygenases are iron-containing enzymes involved in the oxidation of arachidonic acid and other lipids. They carry out the starting step of the synthesis of prostanoids, which are important mediators of several physiological and pathological processes, among which are inflammation, blood clotting, and cancer.
openaire +2 more sources
openaire +2 more sources
Cyclooxygenase-2 in oncogenesis
Clinica Chimica Acta, 2011Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2, the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and epidemiological data indicate that aberrant regulation of cyclooxygenase-2 in certain solid tumors and hematological malignancies is associated with adverse clinical outcome.
openaire +2 more sources