Results 131 to 140 of about 23,800,079 (261)

A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect on platelet function and bleeding diathesis. [PDF]

Am J Hematol, 2021
Palma-Barqueros V, Crescente M, de la Morena ME, Chan MV, Almarza E, Revilla N, Bohdan N, Miñano A, Padilla J, Allan HE, Maffucci T, Edin ML, Zeldin DC, Mesa-Nuñez C, Damian C, Marín-Quilez A, Benito R, Martínez-Martínez I, Bermejo N, Casas-Aviles I, Rodríguez-Alen A, González-Porras JR, Hernández-Rivas JM, Vicente V, Corral J, Lozano ML, Warner TD, Bastida JM, Rivera J.   +28 more
europepmc   +1 more source

Different Catalytically Competent Arrangements of Arachidonic Acid within the Cyclooxygenase Active Site of Prostaglandin Endoperoxide H Synthase-1 Lead to the Formation of Different Oxygenated Products [PDF]

, 2000
Elizabeth D. Thuresson, Karen M. Lakkides, William L. Smith   +2 more
openalex   +1 more source

Different forms of vitamin E and metabolite 13'-carboxychromanols inhibit cyclooxygenase-1 and its catalyzed thromboxane in platelets, and tocotrienols and 13'-carboxychromanols are competitive inhibitors of 5-lipoxygenase. [PDF]

J Nutr Biochem, 2022
Park NY, Im S, Jiang Q.
europepmc   +1 more source

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

Proceedings of the National Academy of Sciences of the United States of America, 2002
N. Chandrasekharan, H. Dai, K. Roos, N. Evanson, Joshua Tomsik, T. Elton, D. Simmons   +6 more
semanticscholar   +1 more source

Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2

Journal of Lipid Research, 2012
Prostaglandin (PG)E2 is relevant in tumor biology, and interactions between tumor and stroma cells dramatically influence tumor progression. We tested the hypothesis that cross-talk between head and neck squamous cell carcinoma (HNSCC) cells and ...
Sonia Alcolea, Rosa Antón, Mercedes Camacho, Marta Soler, Arantzazu Alfranca, Francesc-Xavier Avilés-Jurado, Juan-Miguel Redondo, Miquel Quer, Xavier León, Luis Vila   +9 more
doaj  

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2 [PDF]

, 2000
Olivier Morteau, Scott G. Morham, Rance K. Sellon, Levinus A. Dieleman, Robert Langenbach, Oliver Smithies, R. Balfour Sartor   +6 more
openalex   +1 more source

Interferon Regulatory Factor (Irf)-1 and Irf-2 Regulate Interferon γ–Dependent Cyclooxygenase 2 Expression [PDF]

, 2000
Jorge C. G. Blanco, Cristina Contursi, C A Salkowski, David L. DeWitt, Keiko Ozato, Stefanie N. Vogel   +5 more
openalex   +1 more source

Chemoprevention by Nimesulide, a Selective Cyclooxygenase‐2 Inhibitor, of 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)‐induced Mammary Gland Carcinogenesis in Rats [PDF]

, 2000
Seiichi Nakatsugi, Toshihisa Ohta, Toshihiko Kawamori, Michihiro Mutoh, Tetsuya Tanigawa, Kouji Watanabe, Shigeyuki Sugie, T Sugimura, Keiji Wakabayashi   +8 more
openalex   +1 more source

Brain cyclooxygenase-2 mediates interleukin-1-induced cellular activation in preoptic and arcuate hypothalamus, but not sickness symptoms

Neurobiology of Disease, 2010
Interleukin-1ß acts on the CNS to induce fever, neuroendocrine activation, and behavioral changes, but cannot passively cross the blood–brain barrier. According to a widely accepted hypothesis interleukin-1ß induces the synthesis of cyclooxygenase-2 at ...
Agnès Nadjar, Julie Sauvant, Chantal Combe, Patricia Parnet, Jan Pieter Konsman   +4 more
doaj  

Cyclooxygenase-1 mediates neuroinflammation and neurotoxicity in a mouse model of retinitis pigmentosa. [PDF]

J Neuroinflammation, 2020
Yang W, Xiong G, Lin B.
europepmc   +1 more source