Results 301 to 310 of about 190,703 (326)

CYCLOOXYGENASES 1 AND 2

Annual Review of Pharmacology and Toxicology, 1998
▪ Abstract  Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several laboratories identified a product from a second gene with COX activity and called it COX-2.
J R, Vane, Y S, Bakhle, R M, Botting
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Cyclooxygenase-1 and -2 isoenzymes

The International Journal of Biochemistry & Cell Biology, 1999
The cyclooxygenase isoenzymes (COX-1 and -2) catalyze the rate-limiting steps in prostanoid biosynthesis. COX-1 and -2 genes encode two isoenzymes with overlapping yet distinct expression patterns and functions. Physiologically, various extracellular stimuli such as growth factors, cytokines and tumor promoters regulate the expression of COX-1 and -2 ...
T, Hla, D, Bishop-Bailey, C H, Liu, H J, Schaefers, O C, Trifan   +4 more
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Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation

European Journal of Pharmacology, 1998
The anti-inflammatory activity of drugs more selective for cyclooxgenase isoform inhibition (cyclooxygenase 1, cyclooxygenase 2), were compared in rat carrageenin-induced pleurisy. Suppression of inflammation by cyclooxygenase 2-selective inhibitors, NS-398 (N-[-2-cyclohexyloxy]-4-nitrophenyl methanesulphonamide) and nimesulide (4-nitro-2-phenoxy ...
D W, Gilroy, A, Tomlinson, D A, Willoughby   +2 more
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Cyclooxygenase‐1 and Cyclooxygenase‐2 Inhibition of Novel 1,2‐Disubstituted Imidazoles.

ChemInform, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Handler, Norbert, Jäger, Walter, Kuen-Krismer, Beatrix, Erker, Thomas   +3 more
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Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in the human prostate

Urology, 2000
To determine the cell-specific expression of the two major isoforms of cyclooxygenase (COX-1 and COX-2) in human noncancerous and cancerous prostatic tissues.Thirty-one specimens of prostate carcinoma (CaP) and 10 specimens of benign prostatic hyperplasia (BPH) were stained with mouse antihuman COX-1 and COX-2 monoclonal antibodies.
A, Kirschenbaum, A P, Klausner, R, Lee, P, Unger, S, Yao, X H, Liu, A C, Levine   +6 more
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Cyclooxygenase-1 and Cyclooxygenase-2 in the Human Optic Nerve Head

Experimental Eye Research, 1997
To investigate the hypothesis that eicosanoids act as cellular mediators in the optic nerve head of normals and of patients with glaucoma, we have determined the presence of the two cyclooxygenase (COX) isoforms in human tissue. Histological sections of optic nerve heads were studied by immunohistochemistry. Age matched normal donors were compared with
A H, Neufeld, M R, Hernandez, M, Gonzalez, A, Geller   +3 more
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Cloning and Expression of Cyclooxygenase-1 and Cyclooxygenase-2

2010
Cyclooxygenase (COX) enzymes play important roles in normal physiology and during inflammation of various cells and tissues. In order to help understand the functions of these enzymes, their genes can be cloned to facilitate the production of the proteins in recombinant form.
Nicholas R, Staten, Beverly A, Reitz
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Perspectives on the Cyclooxygenase-2/ Cyclooxygenase-1 Hypothesis

JCR: Journal of Clinical Rheumatology, 1998
The introduction of the cyclooxygenase (COX) hypothesis to explain both the therapeutic effects and the toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) has provided direction for the development of preferential and highly selective COX-2 inhibitors, which retain efficacy against inflammation with reduced risk of toxicity. However, the complex
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Different Methods for Testing Potential Cyclooxygenase-1 and Cyclooxygenase-2 Inhibitors

2010
The need for the development of selective agents, which only inhibit the mainly "harmful" cyclooxygenase-2 (COX-2) while leaving physiological COX-1 mostly unaffected, still remains, especially after the recent issues related to cardiovascular toxicity caused by some COX-2 selective agents.
Stefan, Laufer, Sabine, Luik
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Characteristics of cyclooxygenase-1 and cyclooxygenase-2-deficient mice

1996
The prostaglandins (PGs) are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiological processes. Prostaglandin H2 (PGH2) is an obligate intermediate in formation of prostaglandins1, the formation of which from arachidonic acid (AA) is catalysed by prostaglandin H synthase, an enzyme with two known isoforms ...
S. G. Morham, R. Langenbach
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