Results 311 to 320 of about 190,703 (326)

Ontogeny of cyclooxygenase-1 and cyclooxygenase-2 gene expression in ovine lung

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1998
Prostacyclin is a key mediator of pulmonary vascular and parenchymal function during late fetal and early postnatal life, and its synthesis in whole lung increases during that period. The rate-limiting enzyme in prostacyclin synthesis in the developing lung is cyclooxygenase (COX).
T S, Brannon, A N, MacRitchie, M A, Jaramillo, T S, Sherman, I S, Yuhanna, L R, Margraf, P W, Shaul   +6 more
openaire   +2 more sources

Caveolin‐1 facilitates cyclooxygenase‐2 protein degradation

Journal of Cellular Biochemistry, 2009
AbstractCyclooxygenase‐2 (COX‐2) plays major roles in diverse physiological and pathological processes such as inflammation and tumorigenesis. Transcriptional control of COX‐2 has been extensively investigated and characterized, but its post‐translational control is less clear. Here, we report a novel mechanism by which COX‐2 is degraded.
Shu-Fen, Chen, Jun-Yang, Liou, Tai-Yu, Huang, Yu-Sin, Lin, Ai-Ling, Yeh, Kabik, Tam, Tsung-Huang, Tsai, Kenneth K, Wu, Song-Kun, Shyue   +8 more
openaire   +2 more sources

Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps

Journal of Allergy and Clinical Immunology, 2002
There is evidence that impairment of prostanoid metabolism might be involved in the pathogenesis of nasal polyps (NPs). Prostanoids are synthesized by 2 cyclooxygenase (Cox) enzymes, one constitutive (Cox-1) and another inducible (Cox-2).The aim of these studies was to investigate Cox-1 and Cox-2 regulation in NPs of aspirin-tolerant human patients ...
Joaquim, Mullol, Joan C, Fernàndez-Morata, Jordi, Roca-Ferrer, Laura, Pujols, Antoni, Xaubet, Pedro, Benitez, Cesar, Picado   +6 more
openaire   +2 more sources

Cyclooxygenase-1 and Cyclooxygenase-2 Selectivity of Widely Used Nonsteroidal Anti-Inflammatory Drugs

The American Journal of Medicine, 1998
Both isoforms of cyclo-oxygenase, COX-1 and COX-2, are inhibited to varying degrees by all of the available nonsteroidal anti-inflammatory drugs (NSAIDs). Because inhibition of COX-1 by NSAIDs is linked to gastrointestinal ulcer formation, those drugs that selectively inhibit COX-2 may have less gastrointestinal toxicity.
B, Cryer, M, Feldman
openaire   +2 more sources

Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach

The Histochemical Journal, 1995
Prostaglandins are considered to play important roles in gastric mucosal protection. The rate-limiting enzyme involved in the biosynthesis of prostaglandins is cyclooxygenase (COX), also known as prostaglandin H synthase. Two forms of COX are known: a constitutively expressed form (COX-1) and a newly-characterized, inducible form (COX-2).
openaire   +2 more sources

Evaluation of cyclooxygenase‐1 and cyclooxygenase‐2 expression and the effect of cyclooxygenase inhibitors in canine prostatic carcinoma

Veterinary and Comparative Oncology, 2004
AbstractProstatic carcinoma occurs primarily in older castrated male dogs and is typically a fatal disease (most dogs die within few months after the initial diagnosis). Surgery, i.e., total prostatectomy, or radiation therapy is often not pursued due to risks of complications and a high rate of distant metastasis.
K U, Sorenmo, M H, Goldschmidt, F S, Shofer, C, Goldkamp, J, Ferracone   +4 more
openaire   +2 more sources

‘Bridged’ stilbene derivatives as selective cyclooxygenase-1 inhibitors

Bioorganic & Medicinal Chemistry, 2007
Resveratrol ((E)-3,4',5-trihydroxy-stilbene), a phytoalexin found in various plants, shows non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition. In order to find more selective COX inhibitors a series of bridged stilbene derivatives was synthesized and evaluated for their ability to inhibit both COX-1 and COX-2 in vitro.
Handler, Norbert, Brunhofer, Gerda, Studenik, Christian, Leisser, Klaus, Jäger, Walter, Parth, Stephanie, Erker, Thomas   +6 more
openaire   +3 more sources

Wirkungen von wässerigem Torfextrakt auf die Aktivität der Cyclooxygenase und deren Isoformen Cyclooxygenase-1 und Cyclooxygenase-2

Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin, 2015
Fragestellung: Klinisch werden immer wieder die entzundungshemmenden Wirkungen von Torf bei der Behandlung rheumatologischer Erkrankungen beobachtet. Bislang ist aus der Torfforschung nicht klar hervorgegangen, warum ein Moorbreibad antientzundliche Effekte aufweist. Die thermischen Effekte alleine konnen diese Wirkungen nicht erklaren.
A. Beer, P. Zagorchev, M. Filipova, J. Lukanov   +3 more
openaire   +1 more source

Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.

Cancer research, 2003
Membrane arachidonic acid is converted by cyclooxygenase (COX) into prostaglandin (PG) G(2) and then to PGH(2) which is subsequently metabolized to PGE(2) by PGE synthase (PGES). Both COX-1 and COX-2 play critical roles in intestinal polyp formation, whereas COX-2 is also expressed in cancers of a variety of organs. Likewise, inducible microsomal PGES (
Haruna, Takeda, Masahiro, Sonoshita, Hiroko, Oshima, Ken-ichi, Sugihara, Patricia C, Chulada, Robert, Langenbach, Masanobu, Oshima, Makoto M, Taketo   +7 more
openaire   +1 more source

Cyclooxygenase-1

2007
Burkhard Hinz, Andreas Pahl
openaire   +1 more source