Results 221 to 230 of about 215,861 (352)

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Expression of cyclooxygenase-2 (COX-2) in colorectal adenoma in an indigenous African population in northern Nigeria. [PDF]

Afr J Lab Med
Jimoh AA, Adamu ZA, Rasheed MW, Richard SK.   +3 more
europepmc   +1 more source

Cyclooxygenase-2 expression in keratocystic odontogenic tumour decreased following decompression

, 2013
Jing Wang, Xiaomin Zhang, Xu Ding, Shuzhong Xing, Huaiqi Li, Wei Zhang, Lizhen Wang, Heming Wu   +7 more
openalex   +2 more sources

Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice

, 2020
CarolineBrandão Quines, Simone Pinton, MariaEduarda Ziani Gutierrez, AnneSuély Pinto Savall, Edina da Luz Abreu, Kelly Ayumi Nakama, Renata Bem dos Santos, MarinaCosta Monteiro Guedes, Daiana Silva Ávila, Cristiane Luchese, Sandra Elisa Haas   +10 more
openalex   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Immunohistochemical evaluation of cyclooxygenase-2 expression in feline nasal malignant epithelial tumours. [PDF]

J Feline Med Surg
Diop N, Canonne AM, Huet H, Reyes-Gomez E, Béguin J.   +4 more
europepmc   +1 more source

Potentiation of Excitotoxicity in Transgenic Mice Overexpressing Neuronal Cyclooxygenase-2

, 1999
Kevin A. Kelley, Lap Ho, David Winger, José Freire-Moar, Cy Blanco Borelli, Paul Aisen, Giulio Maria Pasinetti   +6 more
openalex   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis. [PDF]

Ecotoxicol Environ Saf
Zhao L, Wang YF, Adamcakova-Dodd A, Thorne PS, Islam R, Liu KJ, Chen F, Luo J, Liu LZ.   +8 more
europepmc   +1 more source

The Proximal Region of the 3′-Untranslated Region of Cyclooxygenase-2 is Recognized by a Multimeric Protein Complex Containing HuR, TIA-1, TIAR, and the Heterogeneous Nuclear Ribonucleoprotein U [PDF]

, 2003
Steven J. Cok, Stephen J. Acton, Aubrey R. Morrison   +2 more
openalex   +1 more source