Results 241 to 250 of about 215,861 (352)

Somatostatin inhibits colon cancer cell growth through cyclooxygenase‐2 downregulation

, 2008
Rocchina Colucci, Corrado Blandizzi, Narcisa Ghisu, Tullio Florio, Mario Del Tacca   +4 more
openalex   +2 more sources

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Effects of acute selective cyclooxygenase-2 inhibition on skeletal muscle microvascular oxygenation and exercise tolerance. [PDF]

Exp Physiol
Belbis MD, Holmes MJ, Yao J, Kinnick CW, Kargl CK, Day C, Noel NL, Gavin TP, Roseguini BT, Hirai DM.   +9 more
europepmc   +1 more source

Roles of Opioid Receptor Subtype in the Spinal Antinociception of Selective Cyclooxygenase 2 Inhibitor

, 2010
Cheol Hun Choi, Woong Mo Kim, Hyung Gon Lee, Cheol Won Jeong, Chang Mo Kim, Seong Heon Lee, Myung Ha Yoon   +6 more
openalex   +2 more sources

Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain

Advanced Science, EarlyView.
A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio, Tommaso Gili, Andrea Gabrielli, Maurizio Mattia   +3 more
wiley   +1 more source

PET Quantification in Healthy Humans of Cyclooxygenase-2, a Potential Biomarker of Neuroinflammation. [PDF]

J Nucl Med
Yan X, Noergaard M, Morse CL, Liow JS, Hong J, Greve D, Telu S, Kim MJ, Montero Santamaria JA, Galassi A, Feng N, Williams Avram SK, Usdin TB, Wu S, Zhang A, Manly LS, Jenkins M, Van Buskirk M, Lee A, Zoghbi SS, Pike VW, Zanotti-Fregonara P, Innis RB.   +22 more
europepmc   +1 more source

Cyclooxygenase-1 (COX-1); cyclooxygenase-2 (COX-2) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Lysine demethylase 5D promotes CHEK1 inhibitor sensitivity through p38-mediated cyclooxygenase-2 expression in castration-resistant prostate cancer cells. [PDF]

J Pharmacol Exp Ther
Zheng W, Li S, West RE, Donahue ER, Nolin TD, Li S, Wang QJ.   +6 more
europepmc   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source