Results 291 to 300 of about 215,861 (352)

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Exploring the Anti-inflammatory Potential of Novel Chrysin Derivatives through Cyclooxygenase-2 Inhibition. [PDF]

ACS Omega
Lee Y, Gu EJ, Song HY, Yoo BG, Park JE, Jeon J, Byun EB.   +6 more
europepmc   +1 more source

Role of Cyclooxygenase-2 (COX-2) Expression as a Prediction of Persistent Cervical Low Grade Squamous Intraepithelial Lesion (LSIL). [PDF]

Asian Pac J Cancer Prev
Homsup P, Pohthipornthawat N, Ariyasriwatana C, Oranratanaphan S.   +3 more
europepmc   +1 more source

Expression of cyclooxygenase-2 (COX-2) in epithelial ovarian cancers in an Indigenous African population of Kano, Nigeria. [PDF]

Ecancermedicalscience
Abdulrazaq JA, Abdullahi M, Chim NP, Samuel RK.   +3 more
europepmc   +1 more source

Spatiotemporally distinct roles of cyclooxygenase-1 and cyclooxygenase-2 at fetomaternal interface in mice. [PDF]

JCI Insight
Aikawa S, Matsuo M, Akaeda S, Sugimoto Y, Arita M, Isobe Y, Sugiura Y, Taira S, Maeda R, Shimizu-Hirota R, Takeda N, Hiratsuka D, He X, Ishizawa C, Iida R, Fukui Y, Hiraoka T, Harada M, Wada-Hiraike O, Osuga Y, Hirota Y.   +20 more
europepmc   +1 more source

Cyclooxygenase-2 (COX-2)-dependent mechanisms mediate sleep responses to microbial and thermal stimuli. [PDF]

Brain Behav Immun
Szentirmai É, Buckley K, Kapás L.
europepmc   +1 more source

Effects of cyclooxygenase-2 inhibitors on cell proliferation and cell death in human hematopoietic cancer cell lines

, 2011
Cyril Sobolewski
openalex   +1 more source

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Cyclooxygenase-2 in oncogenesis

Clinica Chimica Acta, 2011
Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2, the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and epidemiological data indicate that aberrant regulation of cyclooxygenase-2 in certain solid tumors and hematological malignancies is associated with adverse clinical outcome.
exaly   +3 more sources