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Cloning and Expression of Cyclooxygenase-1 and Cyclooxygenase-2
2010Cyclooxygenase (COX) enzymes play important roles in normal physiology and during inflammation of various cells and tissues. In order to help understand the functions of these enzymes, their genes can be cloned to facilitate the production of the proteins in recombinant form.
Nicholas R, Staten, Beverly A, Reitz
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Perspectives on the Cyclooxygenase-2/ Cyclooxygenase-1 Hypothesis
JCR: Journal of Clinical Rheumatology, 1998The introduction of the cyclooxygenase (COX) hypothesis to explain both the therapeutic effects and the toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) has provided direction for the development of preferential and highly selective COX-2 inhibitors, which retain efficacy against inflammation with reduced risk of toxicity. However, the complex
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Cyclooxygenase-2 and inflammation in atherosclerosis
Current Opinion in Pharmacology, 2004By regulating the production of eicosanoids, cyclooxygenase (COX) modulates processes contributing to atherosclerosis and thrombosis, including platelet aggregation and the local inflammatory response. COX-2, a key mediator of inflammation, is upregulated in activated monocyte/macrophages, suggesting that COX-2 inhibition might reduce atherogenesis ...
MacRae F, Linton, Sergio, Fazio
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Cyclooxygenase-2 as a therapeutic target
Inflammation Research, 1998Cyclooxygenase (COX)-2 is the predominant COX isoform present at sites of inflammation, and produces prostaglandins (PG) that cause swelling and pain. However, in situations where the release of protective PGs by COX-1 has been lost, the induction of COX-2 may compensate and reduce inflammatory responses.
J A, Mitchell, T W, Evans
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Cyclooxygenase‐2 and gastric carcinogenesis
APMIS, 2003Epidemiological studies have shown that the use of nonsteroid anti‐inflammatory drugs (NSAIDs) is associated with reduced risk of gastric cancer. The best‐known target of NSAIDs is the cyclooxygenase (Cox) enzyme. Two Cox genes have been cloned, of which Cox‐2 has been connected with gastric carcinogenesis.
Kirsi, Saukkonen +9 more
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THE ROLE OF CYCLOOXYGENASE-2 IN INFLAMMATION
American Journal of Therapeutics, 1995Prostaglandins (PGs) can be synthetized via two isoforms of cyclooxygenase (COX). COX-1 is constitutively expressed in normal tissues, and its activity represent the normal physiological output of PGs. In inflammatory states, the newly discovered COX-2 is rapidly induced, and its activity accounts for the large amounts of PGs seen in inflammation.
Jaime L., Masferrer +6 more
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Cyclooxygenase-2 and kidney failure
Prostaglandins & Other Lipid Mediators, 2012Cyclooxygenase (COX)-dependent prostaglandins are necessary for normal kidney function. These prostaglandins are associated with inflammation, maintenance of sodium and water homeostasis, control of renin release, renal vasodilation, vasoconstriction attenuation, and prenatal renal development.
Amelia, Rios +3 more
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Cyclooxygenase‐2 in cancer: A review
Journal of Cellular Physiology, 2018AbstractCyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and cancer cell resistance to chemo‐ and radiotherapy. COX‐2 is released by cancer‐associated fibroblasts (CAFs), macrophage type 2 (M2) cells, and cancer cells to the tumor ...
Nasser Hashemi Goradel +4 more
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Cyclooxygenase-2 and Gastrointestinal Cancer
The Cancer Journal, 2004The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin (PG) biosynthesis. Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the enzymatic activity of both COX-1 and COX-2. Selective COX-2 inhibitors have been developed that appear to have 50% less gastrointestinal toxicity than traditional nonselective ...
Jason R, Mann, Raymond N, DuBois
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Cyclooxygenase-2 Expression in Chondrosarcoma
Oncology, 2004<i>Objective:</i> In recent years it has become evident that tissue cyclooxygenase-2 (COX-2) may play a role in carcinogenesis and tumor malignancy. There is now a mounting body of information that strongly implies that COX-2 inhibitors may be of some value in the management of patients with carcinomas, and most recently several similar ...
Karen M, Sutton +4 more
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