Results 321 to 330 of about 215,861 (352)

Cyclooxygenase-2 and Gastric Cancer

Cancer and Metastasis Reviews, 2011
Gastric cancer remains a leading cause of cancer-related deaths worldwide, although its incidence has been steadily declining during recent decades. Expression of cyclooxygenase-2 (COX-2) is elevated in gastric carcinomas and in their precursor lesions.
Alexandra, Thiel, Johanna, Mrena, Ari, Ristimäki   +2 more
openaire   +2 more sources

[Cyclooxygenase-2 and cyclooxygenase-2 inhibitors in prostate cancer].

Zhonghua nan ke xue = National journal of andrology, 2009
Cyclooxygenase-2 (Cox-2) is over-expressed in prostate cancer (PCa) and involved in its development and progression by facilitating inflammatory response, reducing cell apoptosis, increasing angiogenesis and damaging DNA oxidation. Selective Cox-2 inhibitors suppress PCa growth through various channels and therefore have a promising application value ...
Song, Xu, Jian-Ping, Gao, Wen-Quan, Zhou
openaire   +1 more source

Mediation of Inflammation by Cyclooxygenase-2

1995
Non-steroidal antiinflammatory drugs (NSAIDs) are commonly used for the treatment of inflammation, pain, and fever. Mechanistically, these compounds are believed to act via inhibition of the enzyme cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid to the prostaglandins (PGs). Although commercially available NSAIDS are efficacious
K, Seibert, J, Masferrer, Y, Zhang, S, Gregory, G, Olson, S, Hauser, K, Leahy, W, Perkins, P, Isakson   +8 more
openaire   +2 more sources

Cyclooxygenase-2 selective inhibitors

Drugs of Today, 1999
The identification of two cyclooxygenase (COX) enzymes has been a tremendous advance in understanding the role of prostaglandins in inflammation and the actions of nonsteroidal antiinflammatory drugs (NSAIDs). COX-1 activity appears to be related to "constitutive" or "housekeeping" functions in the gastric mucosa, kidney and platelets.
openaire   +2 more sources

Cyclooxygenase-2 Inhibitors

Anesthesia & Analgesia, 2003
openaire   +2 more sources

Regulation of cyclooxygenase activity by metamizol

European Journal of Pharmacology, 1999
Federico Gago, Susana Alemany
exaly  

Compensatory Prostaglandin E2 Biosynthesis in Cyclooxygenase 1 or 2 Null Cells

Journal of Experimental Medicine, 1998
Kanyawim Kirtikara, Takuro Kanekura
exaly  

Malignant Transformation and Antineoplastic Actions of Nonsteroidal Antiinflammatory Drugs (Nsaids) on Cyclooxygenase-Null Embryo Fibroblasts

Journal of Experimental Medicine, 1999
Xinping Zhang
exaly  

Cyclooxygenase-2

2007
Burkhard Hinz, Andreas Pahl
openaire   +1 more source

Accentuated T Helper Type 2 Airway Response after Allergen Challenge in Cyclooxygenase-1 −/− but Not Cyclooxygenase-2 −/− Mice

American Journal of Respiratory and Critical Care Medicine, 2003
Darryl C Zeldin
exaly