Results 131 to 140 of about 106,395 (322)
Synthesis of new 1,2-Benzothiazin-3-one Derivatives Designed as Dual Cyclooxygenase-2 and 5-Lipooxygenase Inhibitors [PDF]
, 1998 Lis H. P. Teixeira +2 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail +3 more
wiley +1 more source
Biologically Active Implants Prevent Mortality in a Mouse Sepsis Model
Advanced Healthcare Materials, EarlyView.A modular, triple‐action titanium implant is developed to prevent implant‐associated infections by repelling bacteria, killing pathogens, and enhancing tissue integration. Coatings with phage cocktails targeting P. aeruginosa and S. aureus show significant bacterial reduction and improved survival in a mouse sepsis model.
Martin Stark +9 more
wiley +1 more source
Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs
Advanced Healthcare Materials, EarlyView.This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani +4 more
wiley +1 more source
Cyclooxygenase-2–selective inhibitors impair glomerulogenesis and renal cortical development [PDF]
, 2000 Martin Kömhoff +6 more
openalex +1 more source
Celecoxib: a selective cyclooxygenase-2 inhibitor [PDF]
Arthritis Research & Therapy, 2003 Selective cyclooxygenase-2 (COX-2) inhibitors were developed to fill an important medical need. The rationale for the development of selective COX-2 inhibitors will be discussed using celecoxib as an example. A brief description of the pharmacology and selective binding to the COX-2 enzyme will be presented.
openaire +1 more source
Advanced Healthcare Materials, EarlyView.This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah +9 more
wiley +1 more source
Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
Journal of Experimental Pharmacology, 2012 Randall E Harris,1 Joanne Beebe,1 Galal A Alshafie21College of Medicine and College of Public Health, 2College of Pharmacy, The Ohio State University, Columbus, Ohio, USAAbstract: We conducted a series of epidemiologic studies to evaluate the ...
Harris RE, Beebe J, Alshafie GA
doaj
Radiation Medicine and ProtectionObjective: To explore the new treatment strategies for radiation proctitis, which is the most common complication of pelvic tumor malignancies. Methods: Four cases of patients with severe radiation proctitis were treated with high-dosage vitamin C (VC ...
Han Wu +6 more
doaj +1 more source
Monocytic myeloid-derived suppressor cells reflect tuberculosis severity and are influenced by cyclooxygenase-2 inhibitors. [PDF]
J Leukoc Biol, 2021 Jøntvedt Jørgensen M +6 more
europepmc +1 more source