Results 181 to 190 of about 995,042 (360)

Synthesis of E-stilbens as Potent Cyclooxygenase-2 Inhibitors and Identification of their Photochemical Products [PDF]

, 2014
Ahmadreza Bekhradnia, Maryam Ahmadian Moghadam, Monire Tatar   +2 more
openalex  

Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors

, 2014
Shankar G. Alegaon, Mita B. Hirpara, K. R. Alagawadi, Kirankumar Hullatti, Kamlesh Kashniyal   +4 more
openalex   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Discovery of Novel Pyridazine-Based Cyclooxygenase-2 Inhibitors with a Promising Gastric Safety Profile. [PDF]

Molecules, 2020
Khan A, Diwan A, Thabet HK, Imran M, Bakht MA.   +4 more
europepmc   +1 more source

337 Celecoxib, a selective cyclooxygenase-2 inhibitor, shows anti-proliferative, pro-apoptotic and anti-fibrotic effects in human hepatic stellate cells

, 2006
Yong‐Han Paik, K.-S. Lee, H.-J. Lee, Sookjin Kang, Seung-Hyun Ahn, Kwang‐Hyub Han, C.Y. Chon, Young-Myoung Moon   +7 more
openalex   +1 more source

Potential <i>Adenostemma lavenia</i> and <i>Muntingia calabura</i> Extracts to Inhibit Cyclooxygenase-2 Activity as a Therapeutic Strategy for Anti-inflammation: Experimental and Theoretical Studies

, 2022
Bagaskoro Tuwalaid, Dyah Iswantini, Setyanto Tri Wahyudi   +2 more
openalex   +2 more sources

Three‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy

Advanced Science, EarlyView.
Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.
Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin   +14 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Roles of Opioid Receptor Subtype in the Spinal Antinociception of Selective Cyclooxygenase 2 Inhibitor

, 2010
Cheol Hun Choi, Woong Mo Kim, Hyung Gon Lee, Cheol Won Jeong, Chang Mo Kim, Seong Heon Lee, Myung Ha Yoon   +6 more
openalex   +2 more sources

Somatostatin inhibits colon cancer cell growth through cyclooxygenase‐2 downregulation

, 2008
Rocchina Colucci, Corrado Blandizzi, Narcisa Ghisu, Tullio Florio, Mario Del Tacca   +4 more
openalex   +1 more source