Results 311 to 320 of about 106,395 (322)

Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation

European Journal of Pharmacology, 1998
The anti-inflammatory activity of drugs more selective for cyclooxgenase isoform inhibition (cyclooxygenase 1, cyclooxygenase 2), were compared in rat carrageenin-induced pleurisy. Suppression of inflammation by cyclooxygenase 2-selective inhibitors, NS-398 (N-[-2-cyclohexyloxy]-4-nitrophenyl methanesulphonamide) and nimesulide (4-nitro-2-phenoxy ...
Annette Tomlinson, Derek W. Gilroy, Derek A. Willoughby   +2 more
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Selective Cyclooxygenase-2 Inhibitors

2004
Publisher Summary Cyclooxygenase (prostaglandin G/H synthase) catalyzes the conversion of arachidonic acid (AA) into prostaglandin H2 as the first committed step of prostaglandin biosynthesis. This enzyme is known to be the target of acetyl salicylic acid (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs).
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The economic implications of cyclooxygenase-2–specific inhibitors

The American Journal of Medicine, 2001
Rheumatoid arthritis and osteoarthritis are prevalent and costly conditions. A large proportion of the direct costs associated with these conditions relates to management of iatrogenic side effects. The cyclooxygenase (COX)-2-specific inhibitors lead to equivalent control of pain and disability compared with traditional NSAIDs.
James M. Scheiman, Paul M. Peloso
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Gastroduodenal Safety of Cyclooxygenase-2 Inhibitors

Current Pharmaceutical Design, 2003
Cyclooxygenase-1 (COX-1) derived eicosanoids promote gastroprotective mucosal defenses and induce platelet aggregation. By sparing COX-1, COX-2 specific inhibitors provide effective anti-inflammatory and analgesic activity while substantially reducing the risk of peptic ulcer disease and GI bleeding compared to dual COX inhibitors (traditional NSAIDs).
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Cardiovascular effects of selective cyclooxygenase-2 inhibitors

Expert Review of Cardiovascular Therapy, 2004
Selective cyclooxygenase-2 inhibitors represent a significant advance in the management of inflammatory disorders. They have similar efficacy to nonselective 'conventional' nonsteroidal anti-inflammatory drugs, but a superior gastrointestinal safety profile.
Henry Krum, Danny Liew, Juan Aw, Steven Joseph Haas   +3 more
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5 Selective Inhibitors of Cyclooxygenase-2 (COT-2)

1999
Publisher Summary This chapter focuses on selective inhibitors of cyclooxygenase-2 (COX-2). Two distinct COX enzymes were recently identified (i) a constitutive form (COX-1) present in tissues such as gut and kidney that produces prostaglandins (PGs) that are necessary for normal physiological function, (ii) an inducible form (COX-2) whose expression
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Correction: Cyclooxygenase-2 Inhibitors

Annals of Pharmacotherapy, 1999
Barbara Storyk Klostermeyer, Barbara Kaplan-Machlis   +1 more
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Cyclooxygenase-2 Inhibitors

Survey of Anesthesiology, 2004
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Aspirin and cyclooxygenase-2 inhibitors

American Journal of Health-System Pharmacy, 2003
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The effect of cyclooxygenase-2 inhibitors on bone healing

Regional Anesthesia and Pain Medicine, 2003
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