Results 141 to 150 of about 7,857 (174)

Role of Cyclophilin A in HIV Replication

Future Virology, 2006
A review. More than a decade has passed since the discovery that the peptidyl prolyl isomerase cyclophilin A (CypA) specifically binds to a proline-rich sequence in HIV-1 capsid (CA) and is thereby incorporated into viral particles. Since then, a variety of possible functions of CypA in the HIV-1 replication cycle have been intensively investigated ...
Votteler, J., Wray, V., Schubert, U.S.
openaire   +2 more sources

Cyclophilin D as a Drug Target

Current Medicinal Chemistry, 2003
The mitochondrial permeability transition (MPT) plays an important role in damage-induced cell death, and agents inhibiting the MPT may have a therapeutic potential for treating human conditions such as ischemia/reperfusion injury, trauma, and neurodegenerative diseases.
Peter C, Waldmeier, Kaspar, Zimmermann, Ting, Qian, Marina, Tintelnot-Blomley, John J, Lemasters   +4 more
openaire   +2 more sources

Redox regulation of cyclophilin A by glutathionylation

PROTEOMICS, 2006
AbstractUsing redox proteomics techniques to characterize the thiol status of proteins in human T lymphocytes, we identified cyclophilin A (CypA) as a specifically oxidized protein early after mitogen activation. CypA is an abundantly expressed cytosolic protein, target of the immunosuppressive drug cyclosporin A (CsA), for which a variety of functions
Ghezzi, Pietro, Casagrande, Simona, Massignan, Tania, Basso, Manuela, Bellacchio, Emanuele, Mollica, Luca, Biasini, Emiliano, Tonelli, Rossella, Eberini, Ivano, Gianazza, Elisabetta, Dai, Wei Wei, Fratelli, Maddalena, Salmona, Mario, Sherry, Barbara, Bonetto, Valentina   +14 more
openaire   +2 more sources

Role of cyclophilin a during oncogenesis

Archives of Pharmacal Research, 2010
Cyclophilins (Cyps) are ubiquitously expressed proteins that are evolutionarily conserved. CypA is the most abundant among the Cyps and is expressed in the cytosol. With its chaperone and PPIase activities, CypA contributes to the maintenance of correct conformation of nascent or denatured proteins and also provides protection against environmental ...
openaire   +2 more sources

Cyclophilin A as a Target of Cisplatin Chemosensitizers

Current Cancer Drug Targets, 2014
Platinum-based chemotherapeutics are the mainstay of treatment of a range of tumors achieving high response rates but limited in the course of disease by appearance of drug resistance. Tumor cells respond with reduced uptake and increased intracellular inactivation of the drugs, as well as increased DNA repair and general resistance to ...
openaire   +2 more sources

The role of cyclophilins in viral infection and the immune response

Journal of Infection, 2022
Zhenling Ma, Wei Liu, Yaru Wu
exaly  

Cyclophilins modify their profile depending on the organ or tissue in a murine inflammatory model

International Immunopharmacology, 2023
Sandra Gegunde, Rebeca Alvarino, Maria Amparo Alfonso Rancaño   +2 more
exaly  

Arabidopsis cyclophilins direct intracellular transport of mobile mRNA via organelle hitchhiking

Nature Plants
Kai-Ren Luo, Nien-Chen Huang, Yu‐Hsin Chang, Y. Jan, Tien-Shin Yu   +4 more
semanticscholar   +1 more source

Microbial cyclophilins: specialized functions in virulence and beyond

World Journal of Microbiology & Biotechnology, 2017
M. Dimou, A. Venieraki, P. Katinakis
semanticscholar   +1 more source

Cyclophilins: The Structure and Functions of an Important Peptidyl-prolyl Isomerase

, 2019
M. Idris, M. Idris, F. Adeola, D. Sedzro
semanticscholar   +1 more source