Results 1 to 10 of about 827 (152)

Suppression of Coronavirus Replication by Cyclophilin Inhibitors

Viruses, 2013
Coronaviruses infect a variety of mammalian and avian species and cause serious diseases in humans, cats, mice, and birds in the form of severe acute respiratory syndrome (SARS), feline infectious peritonitis (FIP), mouse hepatitis, and avian infectious ...
Takashi Sasaki, Sasaki Takashi
exaly   +3 more sources

Inhibitors of Cyclophilin A: Current and Anticipated Pharmaceutical Agents for Inflammatory Diseases and Cancers

Molecules
Cyclophilin A, a widely prevalent cellular protein, exhibits peptidyl-prolyl cis-trans isomerase activity. This protein is predominantly located in the cytosol; additionally, it can be secreted by the cells in response to inflammatory stimuli ...
Xuemei Zhao, Xin Zhao, Weihua Di, Chang Wang   +3 more
exaly   +3 more sources

Cyclophilin inhibition as a strategy for the treatment of human disease

Frontiers in Pharmacology
Cyclophilins (Cyps), characterized as peptidyl-prolyl cis-trans isomerases (PPIases), are highly conserved and ubiquitous, playing a crucial role in protein folding and cellular signaling. This review summarizes the biochemical pathways mediated by Cyps,
Philippe Gallay, Winston Stauffer
exaly   +3 more sources

Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities

Biology, 2023
Proline isomerization, the process of interconversion between the cis- and trans-forms of proline, is an important and unique post-translational modification that can affect protein folding and conformations, and ultimately regulate protein functions and
Deepti Gurung, Jacob A Danielson, Afsara Tasnim, Jian-Ting Zhang, Yue Zou, Jing-Yuan Liu   +5 more
doaj   +1 more source

Cyclosporin A: A Repurposable Drug in the Treatment of COVID-19?

Frontiers in Medicine, 2021
Coronavirus disease 2019 (COVID-19) is now at the forefront of major health challenge faced globally, creating an urgent need for safe and efficient therapeutic strategies.
Christian A. Devaux, Christian A. Devaux, Cléa Melenotte, Marie-Dominique Piercecchi-Marti, Marie-Dominique Piercecchi-Marti, Clémence Delteil, Clémence Delteil, Didier Raoult   +7 more
doaj   +1 more source

Plant Cyclophilins: Multifaceted Proteins With Versatile Roles

Frontiers in Plant Science, 2020
Cyclophilins constitute a family of ubiquitous proteins that bind cyclosporin A (CsA), an immunosuppressant drug. Several of these proteins possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that catalyzes the cis-trans isomerization of the ...
Harpreet Singh, Harpreet Singh, Kirandeep Kaur, Mangaljeet Singh, Gundeep Kaur, Gundeep Kaur, Prabhjeet Singh   +6 more
doaj   +1 more source

Genome-wide characterization and identification of cyclophilin genes associated with leaf rust resistance in bread wheat (Triticum aestivum L.)

Frontiers in Genetics, 2022
Cyclophilins (CYPs) are a group of highly conserved proteins involved in host-pathogen interactions in diverse plant species. However, the role of CYPs during disease resistance in wheat remains largely elusive.
Sandhya Tyagi, Shailendra Kumar Jha, Anuj Kumar, Gautam Saripalli, Ramesh Bhurta, Deepak T. Hurali, Lekshmy Sathee, Niharika Mallick, Reyazul Rouf Mir, Viswanathan Chinnusamy, Vinod   +10 more
doaj   +1 more source

CC-4066 therapy delivered to kidneys during cold storage and assessed with normothermic reperfusion is feasible and safe

Frontiers in Transplantation, 2023
IntroductionCurrently there is an urgent need to translate interventions that may be beneficial to marginal donor kidneys prior to transplant, to improve their quality from bench to bedside. This project investigated the effects of CC-4066, a potent dual
Pommelien Meertens, Pommelien Meertens, Azita Mellati, Richard Dumbill, Richard Dumbill, M. Letizia Lo Faro, Kaithlyn Rozenberg, John Mulvey, Hans Fliri, Rutger Ploeg, Rutger Ploeg, Rutger Ploeg, James Hunter, James Hunter   +13 more
doaj   +1 more source

Association of cyclophilins and cardiovascular risk factors in coronary artery disease

Frontiers in Physiology, 2023
Cyclophilins are chaperone proteins that play important roles in signal transduction. Among them, cyclophilins A, B, C, and D were widely associated with inflammation and cardiovascular diseases. Cyclophilins A and C have been proposed as coronary artery
Sandra Gegunde, Sandra Gegunde, Amparo Alfonso, Amparo Alfonso, Rebeca Alvariño, Rebeca Alvariño, Nadia Pérez-Fuentes, Nadia Pérez-Fuentes, Jeremías Bayón-Lorenzo, Jeremías Bayón-Lorenzo, Eva Alonso, Eva Alonso, Raymundo Ocaranza-Sánchez, Raymundo Ocaranza-Sánchez, Rosa Alba Abellás-Sequeiros, Rosa Alba Abellás-Sequeiros, Melisa Santás-Álvarez, Melisa Santás-Álvarez, Mercedes R. Vieytes, Carlos Juanatey-González, Carlos Juanatey-González, Luis M. Botana, Luis M. Botana   +22 more
doaj   +1 more source

Evidence that intracellular cyclophilin A and cyclophilin A/CD147 receptor-mediated ERK1/2 signalling can protect neurons against in vitro oxidative and ischemic injury

Neurobiology of Disease, 2007
We previously reported that cyclophilin A protein is up-regulated in cortical neuronal cultures following several preconditioning treatments. In the present study, we have demonstrated that adenoviral-mediated over-expression of cyclophilin A in rat ...
Sherif Boulos, Bruno P. Meloni, Peter G. Arthur, Bernadette Majda, Christina Bojarski, Neville W. Knuckey   +5 more
doaj   +1 more source