Results 1 to 10 of about 31,812 (145)
Neurobiology of Disease, 2007 We previously reported that cyclophilin A protein is up-regulated in cortical neuronal cultures following several preconditioning treatments. In the present study, we have demonstrated that adenoviral-mediated over-expression of cyclophilin A in rat ...
Bruno P Meloni +2 more
exaly +3 more sources
Cyclophilin inhibition as a strategy for the treatment of human disease
Frontiers in PharmacologyCyclophilins (Cyps), characterized as peptidyl-prolyl cis-trans isomerases (PPIases), are highly conserved and ubiquitous, playing a crucial role in protein folding and cellular signaling. This review summarizes the biochemical pathways mediated by Cyps,
Winston T Stauffer, Philippe A Gallay
exaly +3 more sources
Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities
Biology, 2023 Proline isomerization, the process of interconversion between the cis- and trans-forms of proline, is an important and unique post-translational modification that can affect protein folding and conformations, and ultimately regulate protein functions and
Deepti Gurung +5 more
doaj +1 more source
Cyclosporin A: A Repurposable Drug in the Treatment of COVID-19?
Frontiers in Medicine, 2021 Coronavirus disease 2019 (COVID-19) is now at the forefront of major health challenge faced globally, creating an urgent need for safe and efficient therapeutic strategies.
Christian A. Devaux +7 more
doaj +1 more source
Plant Cyclophilins: Multifaceted Proteins With Versatile Roles
Frontiers in Plant Science, 2020 Cyclophilins constitute a family of ubiquitous proteins that bind cyclosporin A (CsA), an immunosuppressant drug. Several of these proteins possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that catalyzes the cis-trans isomerization of the ...
Harpreet Singh +6 more
doaj +1 more source
Frontiers in Genetics, 2022 Cyclophilins (CYPs) are a group of highly conserved proteins involved in host-pathogen interactions in diverse plant species. However, the role of CYPs during disease resistance in wheat remains largely elusive.
Sandhya Tyagi +10 more
doaj +1 more source
Frontiers in Transplantation, 2023 IntroductionCurrently there is an urgent need to translate interventions that may be beneficial to marginal donor kidneys prior to transplant, to improve their quality from bench to bedside. This project investigated the effects of CC-4066, a potent dual
Pommelien Meertens +13 more
doaj +1 more source
Association of cyclophilins and cardiovascular risk factors in coronary artery disease
Frontiers in Physiology, 2023 Cyclophilins are chaperone proteins that play important roles in signal transduction. Among them, cyclophilins A, B, C, and D were widely associated with inflammation and cardiovascular diseases. Cyclophilins A and C have been proposed as coronary artery
Sandra Gegunde +22 more
doaj +1 more source
Neural Regeneration Research, 2023 The mitochondrial permeability transition pore is a nonspecific transmembrane channel. Inhibition of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling, calcium overload, and axonal degeneration ...
Yang Yang +12 more
doaj +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source