Results 1 to 10 of about 35,749 (233)

Evidence that intracellular cyclophilin A and cyclophilin A/CD147 receptor-mediated ERK1/2 signalling can protect neurons against in vitro oxidative and ischemic injury

Neurobiology of Disease, 2007
We previously reported that cyclophilin A protein is up-regulated in cortical neuronal cultures following several preconditioning treatments. In the present study, we have demonstrated that adenoviral-mediated over-expression of cyclophilin A in rat ...
Bruno P Meloni, Peter G Arthur, Neville W Knuckey   +2 more
exaly   +3 more sources

Extracellular cyclophilins A and C induce dysfunction of pancreatic microendothelial cells

Frontiers in Physiology, 2022
Extracellular cyclophilins (eCyps) A and B are chemotactic mediators in several illnesses in which inflammation plays an important role such as diabetes and cardiovascular diseases.
Rebeca Alvariño, Rebeca Alvariño, Amparo Alfonso, Amparo Alfonso, Nadia Pérez-Fuentes, Nadia Pérez-Fuentes, Jesús M. González-Jartín, Jesús M. González-Jartín, Sandra Gegunde, Sandra Gegunde, Sandra Gegunde, Mercedes R. Vieytes, Mercedes R. Vieytes, Luis M. Botana, Luis M. Botana   +14 more
doaj   +1 more source

The interaction between Cyclophilin A and CD147 and its clinical significance in periodontal diseases

口腔疾病防治, 2021
Cyclophilin A (CypA) is the first foldable enzyme in human cells that has peptidyl proliferase-trans isomerase activity and has a strong proinflammatory effect. CD147 can act as the signal receptor of CypA. The interaction of the two through cell-surface
YANG Ting, HUANG Shiguang
doaj   +1 more source

Cyclophilin A/EMMPRIN Axis Is Involved in Pro-Fibrotic Processes Associated with Thoracic Aortic Aneurysm of Marfan Syndrome Patients

Cells, 2020
Background: Marfan syndrome (MFS) is a genetic disease, characterized by thoracic aortic aneurysm (TAA), which treatment is to date purely surgical. Understanding of novel molecular targets is mandatory to unveil effective pharmacological approaches ...
Gianluca L. Perrucci, Erica Rurali, Maria Corlianò, Maria Balzo, Michela Piccoli, Donato Moschetta, Alessandro Pini, Raffaella Gaetano, Carlo Antona, Gustavo Egea, Gunter Fischer, Miroslav Malešević, Francesco Alamanni, Elisa Cogliati, Adolfo Paolin, Giulio Pompilio, Patrizia Nigro   +16 more
doaj   +1 more source

Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication

Retrovirology, 2012
Background An understanding of host cell factors that affect viral replication contributes to elucidation of the mechanism for determination of viral tropism.
Takeuchi Hiroaki, Ishii Hiroshi, Kuwano Tetsuya, Inagaki Natsuko, Akari Hirofumi, Matano Tetsuro   +5 more
doaj   +1 more source

Transcriptome Analysis of The Inflammatory Responses of Bovine Mammary Epithelial Cells: Exploring Immunomodulatory Target Genes for Bovine Mastitis

Pathogens, 2020
Bovine mastitis is the inflammatory reaction of the mammary gland and is commonly caused by bacterial infections in high-yielding dairy cows. The detailed investigation of the immunotranscriptomic response of bovine mammary epithelial (BME) cells to ...
Md. Aminul Islam, Michihiro Takagi, Kohtaro Fukuyama, Ryoya Komatsu, Leonardo Albarracin, Tomonori Nochi, Yoshihito Suda, Wakako Ikeda-Ohtsubo, Victor Rutten, Willem van Eden, Julio Villena, Hisashi Aso, Haruki Kitazawa   +12 more
doaj   +1 more source

Cyclophilin A: a novel biomarker for cardiovascular disease in patients with type 2 diabetes

The Egyptian Journal of Internal Medicine, 2019
Background and aims Type 2 diabetes mellitus (DM) is a strong independent risk factor for coronary heart disease. Cyclophilin A (CyPA) is a protein secreted from vascular smooth muscle cells in response to reactive oxygen species.
Manal M Hussain, Emad A.M. Abdel Hady Mohammed, Alyaa A El-Sherbeny, Amira R Shehata   +3 more
doaj   +1 more source

Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions

Frontiers in Immunology, 2021
Cyclophilins (Cyps) are a group of peptidyl-prolyl cis/trans isomerases that play crucial roles in regulatory mechanisms of cellular physiology and pathology in several inflammatory conditions.
Sandra Gegunde, Sandra Gegunde, Amparo Alfonso, Amparo Alfonso, Rebeca Alvariño, Rebeca Alvariño, Eva Alonso, Luis M. Botana, Luis M. Botana   +8 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Predictive value of early second trimester maternal serum cyclophilin A concentrations in women complicated with preeclampsia: a preliminary case–control study

Hypertension in Pregnancy, 2020
Objective To investigate cyclophilin A in early second trimester of pregnancy before the onset of preeclampsia. Methods In this prospective case-control study, 51 pregnant women whose serum were collected and stored and who developed preeclampsia in ...
Samettin Celik, Canan Soyer Çalışkan
doaj   +1 more source