Results 1 to 10 of about 7,857 (174)
Association of cyclophilins and cardiovascular risk factors in coronary artery disease
Frontiers in Physiology, 2023 Cyclophilins are chaperone proteins that play important roles in signal transduction. Among them, cyclophilins A, B, C, and D were widely associated with inflammation and cardiovascular diseases. Cyclophilins A and C have been proposed as coronary artery
Rebeca Alvarino +2 more
exaly +4 more sources
Pathogens, 2021 Cyclophilins are cellular peptidyl-prolyl isomerases that play an important role in viral infections, with demonstrated roles in the replication of hepatitis C virus (HCV) and other viruses in the Flaviviridae family, such as dengue virus (DENV) and ...
Che Colpitts
exaly +4 more sources
Cyclophilins and Their Functions in Abiotic Stress and Plant–Microbe Interactions
Biomolecules, 2021 Plants have developed a variety of mechanisms and regulatory pathways to change their gene expression profiles in response to abiotic stress conditions and plant–microbe interactions. The plant–microbe interaction can be pathogenic or beneficial.
Katarzyna Nuc
exaly +4 more sources
Structural and Functional Insights into Human Nuclear Cyclophilins
Biomolecules, 2018 The peptidyl prolyl isomerases (PPI) of the cyclophilin type are distributed throughout human cells, including eight found solely in the nucleus. Nuclear cyclophilins are involved in complexes that regulate chromatin modification, transcription, and pre ...
Tara Davis
exaly +4 more sources
Plant Cyclophilins: Multifaceted Proteins With Versatile Roles
Frontiers in Plant Science, 2020 Cyclophilins constitute a family of ubiquitous proteins that bind cyclosporin A (CsA), an immunosuppressant drug. Several of these proteins possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that catalyzes the cis-trans isomerization of the ...
Harpreet Singh +6 more
doaj +2 more sources
Mycobacterium tuberculosis cyclophilin A uses novel signal sequence for secretion and mimics eukaryotic cyclophilins for interaction with host protein repertoire. [PDF]
PLoS ONE, 2014 Cyclophilins are prolyl isomerases with multitude of functions in different cellular processes and pathological conditions. Cyclophilin A (PpiA) of Mycobacterium tuberculosis is secreted during infection in intraphagosomal niche.
Asani Bhaduri +10 more
doaj +2 more sources
Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps. [PDF]
PLoS ONE, 2016 Cyclophilins are ubiquitous cis-trans-prolyl isomerases (PPIases) found in all kingdoms of life. Here, we identify a novel family of cyclophilins, termed AquaCyps, which specifically occurs in marine Alphaproteobacteria, but not in related terrestric ...
Roman P Jakob +4 more
doaj +2 more sources
Frontiers in Microbiology, 2022 Brucella spp. are the etiological agent of animal and human brucellosis. We have reported previously that cyclophilins of Brucella (CypA and CypB) are upregulated within the intraphagosomal replicative niche and required for stress adaptation and host ...
Gabriel Briones, Mara Roset
exaly +3 more sources
Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions
Frontiers in Immunology, 2021 Cyclophilins (Cyps) are a group of peptidyl-prolyl cis/trans isomerases that play crucial roles in regulatory mechanisms of cellular physiology and pathology in several inflammatory conditions.
Sandra Gegunde +8 more
doaj +2 more sources
Cyclophilins as Modulators of Viral Replication
Viruses, 2013 Cyclophilins are peptidyl‐prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and ...
Stephen D. Frausto +2 more
doaj +2 more sources