Results 11 to 20 of about 7,857 (174)
Cyclophilins and cyclophilin inhibitors in nidovirus replication
Virology, 2018 Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several of its non-immunosuppressive analogs, which can also block the ...
Adriaan H. de Wilde +3 more
semanticscholar +4 more sources
Genome biology, 2005 SummaryCyclophilins (Enzyme Commission (EC) number 5.1.2.8) belong to a group of proteins that have peptidyl-prolyl cis-trans isomerase activity; such proteins are collectively known as immunophilins and also include the FK-506-binding proteins and the ...
Ping Wang, J. Heitman
semanticscholar +3 more sources
Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion
Virology Journal, 2011 Host cyclophilin (cyp) inhibitors, such as NIM811, efficiently inhibit replication of hepatitis C virus (HCV) and have shown significant promise in recent clinical trials for the treatment of chronic HCV. It is therefore important to fully understand the
Compton Teresa +3 more
doaj +2 more sources
Bioinformatic and expression analysis of the Brassica napus L. cyclophilins
Scientific Reports, 2017 Cyclophilins (CYPs) are a group of ubiquitous proteins characterized by their ability to bind to the immunosuppressive drug cyclosporin A. The CYP family occurs in a wide range of organisms and contains a conserved peptidyl-prolyl cis/trans isomerase ...
Patrizia Hanhart +6 more
doaj +2 more sources
Versatility of Cyclophilins in Plant Growth and Survival: A Case Study in Arabidopsis
Biomolecules, 2019 Cyclophilins (CYPs) belong to a peptidyl-prolyl cis-trans isomerase family, and were first characterized in mammals as a target of an immunosuppressive drug, cyclosporin A, preventing proinflammatory cytokine production.
Izailda Barbosa dos Santos +1 more
doaj +2 more sources
Frontiers in Pharmacology, 2018 The Clostridium botulinum C2 toxin is an exotoxin causing severe enterotoxic symptoms. The C2 toxin consists of the binding/translocation component C2II, and the enzymatic active component C2I.
Holger Barth +2 more
exaly +3 more sources
Extracellular cyclophilins in health and disease
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014 Background Extracellular cyclophilins (eCyPs) are pro-inflammatory factors implicated in pathogenesis of a number of inflammatory diseases. Most pathogenic activities of eCyPs are related to their chemotactic activity towards leukocytes, which is ...
M. Bukrinsky
semanticscholar +3 more sources
Current implications of cyclophilins in human cancers
Journal of Experimental & Clinical Cancer Research, 2010 Cyclophilins (Cyps), the intracellular receptor for immunosuppressant cyclosporine A (CsA), play important cellular roles through activities of peptidyl-prolyl cis-trans isomerase (PPIase) and chaperones. Cyps are structurally conserved and found in both
Kim Sung, Lee Jinhwa
doaj +2 more sources
Target cell cyclophilins facilitate human papillomavirus type 16 infection. [PDF]
PLoS Pathogens, 2009 Following attachment to primary receptor heparan sulfate proteoglycans (HSPG), human papillomavirus type 16 (HPV16) particles undergo conformational changes affecting the major and minor capsid proteins, L1 and L2, respectively.
Malgorzata Bienkowska-Haba +2 more
doaj +2 more sources
PLoS Pathogens, 2011 Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Susanne Pfefferle +27 more
doaj +2 more sources