Results 21 to 30 of about 3,458 (212)
Cyclophilins and cyclophilin inhibitors in nidovirus replication
Virology, 2018 Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several of its non-immunosuppressive analogs, which can also block the replication of nidoviruses (arteriviruses and coronaviruses).
Adriaan H. de Wilde +3 more
openaire +3 more sources
Non‐Immunosuppressive Cyclophilin Inhibitors
Angewandte Chemie International Edition, 2022 AbstractCyclophilins, enzymes with peptidyl‐prolyl cis/trans isomerase activity, are relevant to a large variety of biological processes. The most abundant member of this enzyme family, cyclophilin A, is the cellular receptor of the immunosuppressive drug cyclosporine A (CsA).
Cordelia Schiene‐Fischer +2 more
openaire +4 more sources
A Functional Analysis of the Cyclophilin Repertoire in the Protozoan Parasite Trypanosoma Cruzi
Biomolecules, 2018 Trypanosoma cruzi is the etiological agent of Chagas disease. It affects eight million people worldwide and can be spread by several routes, such as vectorborne transmission in endemic areas and congenitally, and is also important in non-endemic regions ...
Alina E. Perrone +4 more
doaj +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Science-Business eXchange, 2011 In vitro studies suggest cyclosporine A derivatives could help treat coronaviruses such as SARS.
openaire +1 more source
Theileria annulata Cyclophilin1 (TaCyp1) Interacts With Host Cell MED21
Frontiers in Microbiology, 2018 Host cells infected by Theileria annulata schizonts show the character of permanent proliferation in vitro, also named transformation. To explore the molecular mechanism a T.
Shuaiyang Zhao +8 more
doaj +1 more source
Nature Communications, 2022 Cyclophilins are proteins found in many organisms, where they can play roles as chaperones, in signal transduction, or other functions. Here, Yadav et al.
Shivam Yadav +8 more
doaj +1 more source
Toxins, 2018 The Bordetella pertussis toxin (PT) is one important virulence factor causing the severe childhood disease whooping cough which still accounted for approximately 63,000 deaths worldwide in children in 2013.
Katharina Ernst +8 more
doaj +1 more source
Nature Communications, 2016 Cyclophilins play a key role in the life cycle of many viruses and represent important drug targets for broad-spectrum antiviral therapies. Here, the authors use fragment-based drug discovery to develop non-peptidic inhibitors of human cyclophilins with ...
Abdelhakim Ahmed-Belkacem +12 more
doaj +1 more source