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Suppression of Coronavirus Replication by Cyclophilin Inhibitors
Viruses, 2013 Coronaviruses infect a variety of mammalian and avian species and cause serious diseases in humans, cats, mice, and birds in the form of severe acute respiratory syndrome (SARS), feline infectious peritonitis (FIP), mouse hepatitis, and avian infectious ...
Takashi Sasaki +2 more
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Frontiers in Plant Science, 2022 Peptidyl-prolyl cis-trans isomerases (PPIases) are ubiquitous proteins which are essential for cis-trans isomerisation of peptide bonds preceding the proline residue.
Anantika Suri +4 more
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In silico analysis of the cyclophilin repertoire of apicomplexan parasites
Parasites & Vectors, 2009 Background Cyclophilins (Cyps) are peptidyl cis/trans isomerases implicated in diverse processes such as protein folding, signal transduction, and RNA processing.
von Samson-Himmelstjerna Georg +2 more
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Cyclophilin A and viral infections
Biochemical and Biophysical Research Communications, 2012 Cyclophilin A (CyPA) is a peptidyl-prolyl cis/trans isomerase originally identified as the target of the immunosuppressive drug cyclosporine A. A number of reports have demonstrated that CyPA plays a critical role in the successful replication of viruses such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), etc ...
Zhou, Daijun +3 more
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The Arabidopsis Cyclophilin Gene Family [PDF]
Plant Physiology, 2004 AbstractDatabase searching has allowed the identification of a number of previously unreported single and multidomain isoform members of the Arabidopsis cyclophilin gene family. In addition to the cyclophilin-like peptidyl-prolyl cis-trans isomerase domain, the latter contain a variety of other domains with characterized functions.
Patrick G N, Romano +2 more
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[Cyclophilins – proteins with many functions].
Postepy biochemii, 2018 Cyclophilins together with FK-506-binding proteins and parvulins, belong to a group of proteins that have peptidyl-prolyl cis-trans isomerase activity. They also belong to proteins that are collectively known as immunophilins.
Przemysław Olejnik, K. Nuc
semanticscholar +1 more source
Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B
Journal of General Virology, 2017 Feline coronavirus (FCoV) causes the fatal disease feline infectious peritonitis, which is currently incurable by drug treatment, and no effective vaccines are available. Cyclosporin A (CsA), a cyclophilin (Cyp) inhibitor, inhibits the replication of FCoV in vitro and in vivo as well as the replication of human and animal coronaviruses.
Tanaka, Yoshikazu +2 more
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Isoform-Specific Inhibition of Cyclophilins [PDF]
Biochemistry, 2009 Cyclophilins belong to the enzyme class of peptidyl prolyl cis-trans isomerases which catalyze the cis-trans isomerization of prolyl bonds in peptides and proteins in different folding states. Cyclophilins have been shown to be involved in a multitude of cellular functions like cell growth, proliferation, and motility.
Sebastian, Daum +9 more
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BMC Genomics, 2006 Background The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the cis/trans isomerisation of a ...
Pemberton Trevor J
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Cyclophilin B interacts with sodium-potassium ATPase and is required for pump activity in proximal tubule cells of the kidney. [PDF]
PLoS ONE, 2010 Cyclophilins (Cyps), the intracellular receptors for Cyclosporine A (CsA), are responsible for peptidyl-prolyl cis-trans isomerisation and for chaperoning several membrane proteins. Those functions are inhibited upon CsA binding.
Guillermo Suñé +7 more
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