Results 41 to 50 of about 3,458 (212)

In silico analysis of the cyclophilin repertoire of apicomplexan parasites

Parasites & Vectors, 2009
Background Cyclophilins (Cyps) are peptidyl cis/trans isomerases implicated in diverse processes such as protein folding, signal transduction, and RNA processing.
von Samson-Himmelstjerna Georg, Greif Gisela, Krücken Jürgen   +2 more
doaj   +1 more source

Phylogenetic analysis of cyclophilins.

, 2014
A circular phylogram representation of the cyclophilin sequences collected from various taxa. M. tuberculosis PpiA is grouped with eukaryotic and actinobacterial counterparts quite distinct from the prokaryotic clades of cyclophilins.
Abhijit Maji (519936), Gunjan Arora (228014), Lalit Kumar Singh (519938), Asani Bhaduri (248697), Preetida J. Bhetaria (519937), Neha Dubey (519940), Jugsharan Singh Virdi (414403), Yogendra Singh (8247), Richa Misra (519935), Neha Dhasmana (519939), Sonakshi Mishra (214789)   +10 more
core   +1 more source

The SARS-coronavirus-host interactome [PDF]

, 2011
Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Brunn, Albrecht von, Steffen, Imke, Kögl, Manfred, Schwegmann-Wessels, Christel, Pumpor, Ksenia, Müller, Marcel A., Herzog, Petra, Kuri, Thomas, Ditt, Vanessa, Weber, Friedemann, Schwarz, Frank, Pfefferle, Susanne, Schöpf, Julia, Kallies, Stefan, Herrler, Georg, Carbajo-Lozoya, Javier, Zimmer, Ralf, Hilgenfeld, Rolf, Friedel, Caroline C., Dall'Armi, Ekatarina von, Drosten, Christian, Niemeyer, Daniela, Thiel, Volker, Züst, Roland, Stellberger, Thorsten, Thiel, Heinz-Jürgen, Pöhlmann, Stefan, Haas, Juergen G.   +27 more
core   +1 more source

Cyclophilin A and viral infections

Biochemical and Biophysical Research Communications, 2012
Cyclophilin A (CyPA) is a peptidyl-prolyl cis/trans isomerase originally identified as the target of the immunosuppressive drug cyclosporine A. A number of reports have demonstrated that CyPA plays a critical role in the successful replication of viruses such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), etc ...
Zhou, Daijun, Mei, Qiang, Li, Jintao, He, Haiyang   +3 more
openaire   +2 more sources

Isoform-Specific Inhibition of Cyclophilins [PDF]

Biochemistry, 2009
Cyclophilins belong to the enzyme class of peptidyl prolyl cis-trans isomerases which catalyze the cis-trans isomerization of prolyl bonds in peptides and proteins in different folding states. Cyclophilins have been shown to be involved in a multitude of cellular functions like cell growth, proliferation, and motility.
Sebastian, Daum, Michael, Schumann, Sebastian, Mathea, Tobias, Aumüller, Molly A, Balsley, Stephanie L, Constant, Boris Féaux, de Lacroix, Fabian, Kruska, Manfred, Braun, Cordelia, Schiene-Fischer   +9 more
openaire   +2 more sources

Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B

Journal of General Virology, 2017
Feline coronavirus (FCoV) causes the fatal disease feline infectious peritonitis, which is currently incurable by drug treatment, and no effective vaccines are available. Cyclosporin A (CsA), a cyclophilin (Cyp) inhibitor, inhibits the replication of FCoV in vitro and in vivo as well as the replication of human and animal coronaviruses.
Tanaka, Yoshikazu, Sato, Yuka, Sasaki, Takashi   +2 more
openaire   +2 more sources

Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires

BMC Genomics, 2006
Background The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the cis/trans isomerisation of a ...
Pemberton Trevor J
doaj   +1 more source

Cyclophilins in T. inflatum genome.

, 2013
A) Backbone of maximum likelihood phylogeny of major cyclophilins from T. inflatum, H. sapiens, C. elegans, D. melanogaster, and characterized cyclophilins from other fungi, bacteria, and protists (Figure S7) showing phylogenetic positions of the ten T ...
Jason S. Cumbie (24080), Daniel Miller (424185), C. Alisha Owensby (424182), Yanming Di (91480), Kathryn E. Bushley (276523), Brian J. Knaus (424183), Joseph W. Spatafora (114854), Justin Elser (424184), Rajani Raja (424180), Mariko Nonogaki (109033), Alexander E. Boyd (424181), Kerry L. McPhail (418940), Pankaj Jaiswal (14313)   +12 more
core   +1 more source

Cyclophilin B interacts with sodium-potassium ATPase and is required for pump activity in proximal tubule cells of the kidney. [PDF]

PLoS ONE, 2010
Cyclophilins (Cyps), the intracellular receptors for Cyclosporine A (CsA), are responsible for peptidyl-prolyl cis-trans isomerisation and for chaperoning several membrane proteins. Those functions are inhibited upon CsA binding.
Guillermo Suñé, Eduard Sarró, Marta Puigmulé, Joan López-Hellín, Madeleine Zufferey, Thomas Pertel, Jeremy Luban, Anna Meseguer   +7 more
doaj   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source