Results 61 to 70 of about 3,458 (212)
Multiple cyclophilins involved in different cellular pathways mediate HCV replication
, 2010 Three cyclophilin inhibitors (DEBIO-025, SCY635, and NIM811) are currently in clinical trials for hepatitis C therapy. The mechanism of action of these, however, is not completely understood.
Baryza, Jeremy +18 more
core +1 more source
Cells, 2019 Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor survival and an increased risk of developing hepatocellular carcinoma, with limited treatment ...
Sonia Simón Serrano +12 more
doaj +1 more source
Comparative analysis of biochemical parameters of various cyclophilins.
, 2015 Comparative analysis of biochemical parameters of various cyclophilins.
Sanjay Kapoor (43319) +10 more
core +1 more source
Cyclophilin Succumbs to a Macrocyclic Chameleon [PDF]
Journal of Medicinal Chemistry, 2018 Targets that have large and groove-shaped binding sites, such as cyclophilin, are difficult to drug with small molecules. Macrocycles of natural product origin can be ideal starting points for such targets as illustrated by the transformation of sanglifehrin A into an orally bioavailable potential candidate drug.
Bradley C. Doak, Jan Kihlberg
openaire +2 more sources
Roles of Prolyl Isomerases in RNA-Mediated Gene Expression
Biomolecules, 2015 The peptidyl-prolyl cis-trans isomerases (PPIases) that include immunophilins (cyclophilins and FKBPs) and parvulins (Pin1, Par14, Par17) participate in cell signaling, transcription, pre-mRNA processing and mRNA decay.
Roopa Thapar
doaj +1 more source
Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions
Frontiers in Immunology, 2021 Cyclophilins (Cyps) are a group of peptidyl-prolyl cis/trans isomerases that play crucial roles in regulatory mechanisms of cellular physiology and pathology in several inflammatory conditions.
Sandra Gegunde +8 more
doaj +1 more source
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
S-cyclophilin. New member of the cyclophilin family associated with the secretory pathway
Journal of Biological Chemistry, 1991 Cyclophilin is an abundant and ubiquitous cytosolic protein that is conserved throughout evolution from man to bacteria. It is the target of the immunosuppressive drug cyclosporin A. Cyclophilin has peptidyl-prolyl cis/trans-isomerase activity, and it accelerates protein folding in vitro, suggesting that it might be involved in the folding of cytosolic
P, Caroni +3 more
openaire +2 more sources
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan +9 more
wiley +1 more source
Cyclophilins and gibberellin-regulated proteins in IgE-mediated allergic diseases
, 2023 International audienceThe prevalence of immunoglobulin E (IgE)-mediated allergic diseases is currently experiencing an epidemic trend characterized by an increase in both the number of affected individuals and the proportion of patients with multiple ...
Sénéchal, Hélène +9 more
core +1 more source