Results 61 to 70 of about 7,857 (174)

Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. [PDF]

PLoS Pathogens, 2009
Viruses are obligate intracellular parasites and therefore their replication completely depends on host cell factors. In case of the hepatitis C virus (HCV), a positive-strand RNA virus that in the majority of infections establishes persistence ...
Artur Kaul, Sarah Stauffer, Carola Berger, Thomas Pertel, Jennifer Schmitt, Stephanie Kallis, Margarita Zayas, Volker Lohmann, Jeremy Luban, Ralf Bartenschlager   +9 more
doaj   +1 more source

Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis

Cells, 2019
Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor survival and an increased risk of developing hepatocellular carcinoma, with limited treatment ...
Sonia Simón Serrano, Alvar Grönberg, Lisa Longato, Krista Rombouts, Joseph Kuo, Matthew Gregory, Steven Moss, Eskil Elmér, Giuseppe Mazza, Philippe Gallay, Massimo Pinzani, Magnus J. Hansson, Ramin Massoumi   +12 more
doaj   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Depletion of Cyclophilins B and C Leads to Dysregulation of Endoplasmic Reticulum Redox Homeostasis*

Journal of Biological Chemistry, 2014
Background: Cyclophilins catalyze cis-trans isomerization of peptidyl-prolyl bonds. Results: Depletion of cyclophilins B and C results in endoplasmic reticulum (ER) hyperoxidation including more oxidized protein-disulfide isomerase enzymes and elevated ...
P. Stocki, D. C. Chapman, Lori A. Beach, David B. Williams   +3 more
semanticscholar   +1 more source

Cyclophilin Succumbs to a Macrocyclic Chameleon [PDF]

Journal of Medicinal Chemistry, 2018
Targets that have large and groove-shaped binding sites, such as cyclophilin, are difficult to drug with small molecules. Macrocycles of natural product origin can be ideal starting points for such targets as illustrated by the transformation of sanglifehrin A into an orally bioavailable potential candidate drug.
Bradley C. Doak, Jan Kihlberg
openaire   +2 more sources

Roles of Prolyl Isomerases in RNA-Mediated Gene Expression

Biomolecules, 2015
The peptidyl-prolyl cis-trans isomerases (PPIases) that include immunophilins (cyclophilins and FKBPs) and parvulins (Pin1, Par14, Par17) participate in cell signaling, transcription, pre-mRNA processing and mRNA decay.
Roopa Thapar
doaj   +1 more source

Assessment of Attainable Distances in Proteins by Through‐Space 19F–19F Couplings

Chemistry – A European Journal, EarlyView.
De novo synthesized difluorinated tryptophan analogues are site‐specifically incorporated into Cyclophilin A (CypA). 19F–19F NOESY build‐up experiments are recorded for each labeled protein, and the distances derived from cross‐relaxation rates are compared to reference distances.
Iker Hernández, In‐Ja L. Byeon, Christina M. Monnie, Vadim A. Soloshonok, Aitor Landa, Mikel Oiarbide, Angela M. Gronenborn   +6 more
wiley   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Alisporivir Inhibition of Hepatocyte Cyclophilins Reduces HBV Replication and Hepatitis B Surface Antigen Production

Gastroenterology, 2014
Background & Aims Cyclophilins are host factors required for hepatitis C virus replication. Cyclophilin inhibitors such as alisporivir have shown strong anti–hepatitis C virus activity in vitro and in clinical studies.
S. Phillips, S. Chokshi, U. Chatterji, A. Riva, M. Bobardt, Roger Williams, P. Gallay, N. Naoumov   +7 more
semanticscholar   +1 more source

Optimization of the antiviral spectrum of cyclophilin inhibitors targeting respiratory viruses

Antimicrobial Agents and Chemotherapy
We evaluated the antiviral activity of a library of 36 urea-based small-molecule cyclophilin inhibitors (SMCypIs) against human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV).
Laurent Softic, Bryan Jimenez-Araya, Nazim Ahnou, Maxime Duval, Quentin Nevers, Rozenn Brillet, Jean-Francois Guichou, Christophe Rodriguez, Patrice Bruscella, Jean-Michel Pawlotsky, Slim Fourati, Abdelhakim Ahmed-Belkacem   +11 more
doaj   +1 more source