Results 71 to 80 of about 3,458 (212)
Stereo views of cocrystal structures of cyclophilins with cyclophilin inhibitors.pdf
, 2016 Cocrystal structures (stereo views of sections of the electron density maps) of cyclophilin D complexed with different compounds from a new family of nonpeptidic, small-molecule cyclophilin ...
Jean-Michel Pawlotsky +12 more
openaire +1 more source
A cDNA Clone for Cyclophilin from Griffithsia japonica and Phylogenetic Analysis of Cyclophilins
Molecules and Cells, 2002 A cDNA clone, designated as Griffithsia japonica cyclophilin-1 (GjCyp-1), was isolated by differential screening of a cDNA library for a red alga, G. japonica. The transcript that corresponded to GjCyp-1 was abundant in vegetative, male, and tetrasporangial thalli, but only the basal level of the transcript was detected in female gametophytes ...
Yoo Kyung, Lee +3 more
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Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley +1 more source
, 2004 Cyclophilins are folding helper enzymes and represent a family of the enzyme class of peptidyl-prolyl cis–trans isomerases. Here, we report the molecular cloning and biochemical characterization of SanCyp18, an 18-kDa cyclophilin from Streptomyces ...
Fanghanel, Jorg +9 more
core +1 more source
An endoplasmic reticulum-specific cyclophilin. [PDF]
Molecular and Cellular Biology, 1991 Cyclophilin is a ubiquitously expressed cytosolic peptidyl-prolyl cis-trans isomerase that is inhibited by the immunosuppressive drug cyclosporin A. A degenerate oligonucleotide based on a conserved cyclophilin sequence was used to isolate cDNA clones representing a ubiquitously expressed mRNA from mice and humans.
K W, Hasel +3 more
openaire +2 more sources
VIEW, EarlyView.Mitochrial transplantation is a promising therapy to restore energy in damaged cells, but it lacks fast and reliable methods to assess mitochondrial quality before use. In this study, we used a label‐free imaging technique called interferometric light microscopy to rapidly measure the size and concentration of isolated mitochondria.
Sabah Mozafari +5 more
wiley +1 more source
British Journal of Haematology, EarlyView.Summary Diffuse large B‐cell lymphoma (DLBCL) is the most common aggressive non‐Hodgkin lymphoma and is characterized by substantial heterogeneity. This study aimed to develop a liquid–liquid phase separation (LLPS)‐related prognostic model to improve risk stratification.
Zhen‐Zhong Zhou +11 more
wiley +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice
The FEBS Journal, EarlyView.Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan +8 more
wiley +1 more source
Evolving treatments for Sjögren disease: current approaches and emerging targets
Internal Medicine Journal, EarlyView.Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani +3 more
wiley +1 more source