Results 31 to 40 of about 7,857 (174)

Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Bordetella pertussis Toxin

Toxins, 2018
The Bordetella pertussis toxin (PT) is one important virulence factor causing the severe childhood disease whooping cough which still accounted for approximately 63,000 deaths worldwide in children in 2013.
Katharina Ernst, Nina Eberhardt, Ann-Katrin Mittler, Michael Sonnabend, Anna Anastasia, Simon Freisinger, Cordelia Schiene-Fischer, Miroslav Malešević, Holger Barth   +8 more
doaj   +1 more source

Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium

Nature Communications, 2022
Cyclophilins are proteins found in many organisms, where they can play roles as chaperones, in signal transduction, or other functions. Here, Yadav et al.
Shivam Yadav, Martin Centola, Mathilda Glaesmann, Denys Pogoryelov, Roman Ladig, Mike Heilemann, L. C. Rai, Özkan Yildiz, Enrico Schleiff   +8 more
doaj   +1 more source

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

Nature Communications, 2016
Cyclophilins play a key role in the life cycle of many viruses and represent important drug targets for broad-spectrum antiviral therapies. Here, the authors use fragment-based drug discovery to develop non-peptidic inhibitors of human cyclophilins with ...
Abdelhakim Ahmed-Belkacem, Lionel Colliandre, Nazim Ahnou, Quentin Nevers, Muriel Gelin, Yannick Bessin, Rozenn Brillet, Olivier Cala, Dominique Douguet, William Bourguet, Isabelle Krimm, Jean-Michel Pawlotsky, Jean- François Guichou   +12 more
doaj   +1 more source

Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication

Antiviral Research, 2019
The well-known immunosuppressive drug cyclosporin A inhibits replication of various viruses including coronaviruses by binding to cellular cyclophilins thus inactivating their cis-trans peptidyl-prolyl isomerase function.
Yue Ma-Lauer, Yu Zheng, M. Malešević, B. von Brunn, G. Fischer, A. von Brunn   +5 more
semanticscholar   +1 more source

Mycobacterium tuberculosis Peptidyl-Prolyl Isomerases Also Exhibit Chaperone like Activity In-Vitro and In-Vivo. [PDF]

PLoS ONE, 2016
Peptidyl-prolyl cis-trans isomerases (Ppiases), also known as cyclophilins, are ubiquitously expressed enzymes that assist in protein folding by isomerization of peptide bonds preceding prolyl residues.
Saurabh Pandey, Ashish Sharma, Deeksha Tripathi, Ashutosh Kumar, Mohd Khubaib, Manish Bhuwan, Tapan Kumar Chaudhuri, Seyed Ehtesham Hasnain, Nasreen Zafar Ehtesham   +8 more
doaj   +1 more source

Cyclophilin Inhibitors: An Emerging Class of Therapeutics for the Treatment of Chronic Hepatitis C Infection

Viruses, 2012
The advent of the replicon system together with advances in cell culture have contributed significantly to our understanding of the function of virally-encoded structural and nonstructural proteins in the replication cycle of the hepatitis C virus.
Philippe Gallay, Sam Hopkins
doaj   +1 more source

Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides

Angewandte Chemie, EarlyView.
Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi, Mariko Akiba, Marin Yokomine, Masatake Sugita, Koji Umezawa, Yuto Hirota, Yutaka Akiyama, Jumpei Morimoto, Shinsuke Sando   +8 more
wiley   +2 more sources

All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae

Proceedings of the National Academy of Sciences of the United States of America, 1997
Joseph Heitman, Kara Doliński, Heitman Joseph   +2 more
exaly   +2 more sources

Genome-wide characterization of peptidyl-prolyl  cis–trans  isomerases in Penicillium and their regulation by salt stress in a halotolerant P. oxalicum

Scientific Reports, 2021
Peptidyl-prolyl cis–trans isomerases (PPIases) are the only class of enzymes capable of cis–trans isomerization of the prolyl peptide bond. The PPIases, comprising of different families viz., cyclophilins, FK506-binding proteins (FKBPs), parvulins and ...
Mangaljeet Singh, Kirandeep Kaur, Avinash Sharma, Rajvir Kaur, Dimple Joshi, Megha Chatterjee, Iman Dandapath, Amarjeet Kaur, Harpreet Singh, Prabhjeet Singh   +9 more
doaj   +1 more source

IgE to cyclophilins in pollen allergic children: epidemiological, clinical and diagnostic relevance of a neglected panallergen.

Journal of Allergy and Clinical Immunology
BACKGROUND - Cyclophilins are ubiquitous panallergens whose epidemiological, diagnostic, and clinical relevance is largely unknown and whose sensitization is rarely examined in routine allergy practice.
P. Matricardi, E. Potapova, Valentina Panetta, J. Lidholm, L. Mattsson, E. Scala, R. Bernardini, C. Caffarelli, Antonella Casani, Rosa Cervone, L. Chini, P. Comberiati, G. De Castro, M. Miraglia del Giudice, I. dello Iacono, A. Di Rienzo Businco, Marcella Gallucci, A. Giannetti, Viviana Moschese, E. Varin, Annamaria Bianchi, Mauro Calvani, T. Frediani, Francesco Macrì, N. Maiello, F. Paravati, Umberto Pelosi, D. Peroni, G. Pingitore, M. Tosca, A. Zicari, G. Ricci, Riccardo Asero, S. Tripodi   +33 more
semanticscholar   +1 more source