Results 21 to 30 of about 35,749 (233)
Cyclophilins and cyclophilin inhibitors in nidovirus replication
Virology, 2018 Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several of its non-immunosuppressive analogs, which can also block the replication of nidoviruses (arteriviruses and coronaviruses).
Adriaan H. de Wilde +3 more
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Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps [PDF]
, 2016 Cyclophilins are ubiquitous cis-trans-prolyl isomerases (PPIases) found in all kingdoms of life. Here, we identify a novel family of cyclophilins, termed AquaCyps, which specifically occurs in marine Alphaproteobacteria, but not in related terrestric ...
Timm Maier +14 more
core +1 more source
Secreted extracellular cyclophilin a is a novel mediator of ventilator induced lung injury. [PDF]
, 2021 RATIONALE: Mechanical ventilation is a mainstay of intensive care but contributes to the mortality of patients through ventilator induced lung injury. Extracellular Cyclophilin A is an emerging inflammatory mediator and metalloproteinase inducer, and the
Baldi, Rhianna F +17 more
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Association of cyclophilins and cardiovascular risk factors in coronary artery disease
Frontiers in Physiology, 2023 Cyclophilins are chaperone proteins that play important roles in signal transduction. Among them, cyclophilins A, B, C, and D were widely associated with inflammation and cardiovascular diseases. Cyclophilins A and C have been proposed as coronary artery
Sandra Gegunde +22 more
doaj +1 more source
Science-Business eXchange, 2011 In vitro studies suggest cyclosporine A derivatives could help treat coronaviruses such as SARS.
openaire +1 more source
Neural Regeneration Research, 2023 The mitochondrial permeability transition pore is a nonspecific transmembrane channel. Inhibition of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling, calcium overload, and axonal degeneration ...
Yang Yang +12 more
doaj +1 more source
Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation [PDF]
, 2009 CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis–trans isomerases). In some experimental models, CsA offers partial protection against lethal cell injury brought about by ...
Crompton, M. +7 more
core +1 more source
Nicht-immunsuppressive Cyclophilin-Inhibitoren [PDF]
, 2022 Cyclophiline, Enzyme mit einer Peptidyl-Prolyl-cis/trans-Isomerase-Aktivität, sind für eine Vielzahl biologischer Prozesse von Bedeutung. Das am häufigsten vorkommende Mitglied dieser Enzymfamilie, Cyclophilin A, ist der zelluläre Rezeptor des ...
Schiene-Fischer, Cordelia +2 more
core +1 more source
Parasites & Vectors, 2020 Background New therapeutic drugs are urgently needed against visceral leishmaniasis because current drugs, such as pentavalent antimonials and miltefosine, produce severe side effects and development of resistance.
Zhi-Wan Zheng +8 more
doaj +1 more source
SIV replication in human cells
Frontiers in Microbiology, 2012 Current human immunodeficiency virus type 1 (HIV-1) pandemic is believed to originate from cross-species transmission of simian immunodeficiency virus (SIV) into human population.
Hiroaki eTakeuchi, Ryuta eSakuma
doaj +1 more source