Results 21 to 30 of about 31,837 (203)
FASEB BioAdvances, 2021 Macrophage apoptosis is a key contributor to the progression of atherosclerosis. Cyclophilin A, a monocyte secretory protein associated with the initiation of atherosclerosis has an inherent nuclease activity.
Vinitha Anandan +7 more
doaj +1 more source
Genome biology, 2005 Cyclophilins (Enzyme Commission (EC) number 5.1.2.8) belong to a group of proteins that have peptidyl-prolyl cis-trans isomerase activity; such proteins are collectively known as immunophilins and also include the FK-506-binding proteins and the parvulins. Cyclophilins are found in all cells of all organisms studied, in both prokaryotes and eukaryotes;
Wang, Ping, Heitman, Joseph
openaire +2 more sources
Analyses of the toxic properties of recombinant human Cyclophilin A in mice
Journal of Immunotoxicology, 2019 Cyclophilin A (CypA), an 18 kDa multi-functional protein with cis–trans isomerase activity, is both a ligand for cyclosporine A and a proinflammatory factor. CypA is also a chemoattractant for hemopoietic stem cells and progenitors of different lineages,
Anastasiya Kalinina +6 more
doaj +1 more source
Hypertension in Pregnancy, 2017 Objective: To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level.
Noroyono Wibowo +3 more
doaj +1 more source
BMC Genomics, 2022 Background Cyclophilin (CYP) belongs to the immunophilin family and has peptidyl-prolyl cis-trans isomerase (PPIase) activity, which catalyzes the cis-trans isomerization process of proline residues.
Zhi-Wen Qiao +4 more
doaj +1 more source
Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides
Angewandte Chemie, EarlyView.Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi +8 more
wiley +2 more sources
Cells, 2021 Impairment of efferocytosis in apoptotic macrophages is a known determinant of the severity of atherosclerosis and the vulnerability of plaques to rupture. The precise mechanisms involved in impaired efferocytosis are unclear.
Vinitha Anandan +8 more
doaj +1 more source
Study of Cyclophilin_ A in Egyptian Patients with Chronic Heart Failure Diseases [PDF]
Research Journal of Applied Biotechnology, 2022 Background. A Clinical phenomenon that has historically been categorized as a condition where the heart's ability to pump and fill with blood is diminished is known as a Heart failure (HF), which is still the world's number one cause of death.
Ahmed Hassanain +4 more
doaj +1 more source
Cyclophilin B serum levels present variations across the menstrual cycle
Scientific Reports, 2023 Cyclophilins are a family of chaperones involved in inflammation and cell death. Cyclophilin B is released by inflammatory cells and acts through the receptor CD147, affecting matrix metalloproteases release, whilst cyclophilin D participates in hypoxia ...
Rebeca Alvariño +7 more
doaj +1 more source
Molecular Dynamic Simulation and Docking of Cyclophilin A Mutants with its Potential Inhibitors
Journal of Clinical and Basic Research, 2021 Background and objectives: Cyclophilin A (CypA) is involved in various human biological processes. Its role in many pathological conditions makes it a promising target for treating human diseases, such as viral infections.
Alireza Mohebbi +4 more
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