Results 11 to 20 of about 31,837 (203)

Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions

open access: yesFrontiers in Immunology, 2021
Cyclophilins (Cyps) are a group of peptidyl-prolyl cis/trans isomerases that play crucial roles in regulatory mechanisms of cellular physiology and pathology in several inflammatory conditions.
Sandra Gegunde   +8 more
doaj   +1 more source

Predictive value of early second trimester maternal serum cyclophilin A concentrations in women complicated with preeclampsia: a preliminary case–control study

open access: yesHypertension in Pregnancy, 2020
Objective To investigate cyclophilin A in early second trimester of pregnancy before the onset of preeclampsia. Methods In this prospective case-control study, 51 pregnant women whose serum were collected and stored and who developed preeclampsia in ...
Samettin Celik, Canan Soyer Çalışkan
doaj   +1 more source

Association of cyclophilins and cardiovascular risk factors in coronary artery disease

open access: yesFrontiers in Physiology, 2023
Cyclophilins are chaperone proteins that play important roles in signal transduction. Among them, cyclophilins A, B, C, and D were widely associated with inflammation and cardiovascular diseases. Cyclophilins A and C have been proposed as coronary artery
Sandra Gegunde   +22 more
doaj   +1 more source

Cyclophilin [PDF]

open access: yesScience-Business eXchange, 2011
In vitro studies suggest cyclosporine A derivatives could help treat coronaviruses such as SARS.
openaire   +1 more source

Non‐Immunosuppressive Cyclophilin Inhibitors

open access: yesAngewandte Chemie International Edition, 2022
AbstractCyclophilins, enzymes with peptidyl‐prolyl cis/trans isomerase activity, are relevant to a large variety of biological processes. The most abundant member of this enzyme family, cyclophilin A, is the cellular receptor of the immunosuppressive drug cyclosporine A (CsA).
Cordelia Schiene‐Fischer   +2 more
openaire   +4 more sources

CAQ Corner: Basic concepts of transplant immunology

open access: yes, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Cyclophilin D-induced mitochondrial impairment confers axonal injury after intracerebral hemorrhage in mice

open access: yesNeural Regeneration Research, 2023
The mitochondrial permeability transition pore is a nonspecific transmembrane channel. Inhibition of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling, calcium overload, and axonal degeneration ...
Yang Yang   +12 more
doaj   +1 more source

Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A

open access: yesParasites & Vectors, 2020
Background New therapeutic drugs are urgently needed against visceral leishmaniasis because current drugs, such as pentavalent antimonials and miltefosine, produce severe side effects and development of resistance.
Zhi-Wan Zheng   +8 more
doaj   +1 more source

SIV replication in human cells

open access: yesFrontiers in Microbiology, 2012
Current human immunodeficiency virus type 1 (HIV-1) pandemic is believed to originate from cross-species transmission of simian immunodeficiency virus (SIV) into human population.
Hiroaki eTakeuchi, Ryuta eSakuma
doaj   +1 more source

Evidence that intracellular cyclophilin A and cyclophilin A/CD147 receptor-mediated ERK1/2 signalling can protect neurons against in vitro oxidative and ischemic injury

open access: yesNeurobiology of Disease, 2007
We previously reported that cyclophilin A protein is up-regulated in cortical neuronal cultures following several preconditioning treatments. In the present study, we have demonstrated that adenoviral-mediated over-expression of cyclophilin A in rat ...
Sherif Boulos   +5 more
doaj   +1 more source

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