Results 31 to 40 of about 35,749 (233)

The cyclophilins.

Genome biology, 2005
Cyclophilins (Enzyme Commission (EC) number 5.1.2.8) belong to a group of proteins that have peptidyl-prolyl cis-trans isomerase activity; such proteins are collectively known as immunophilins and also include the FK-506-binding proteins and the parvulins. Cyclophilins are found in all cells of all organisms studied, in both prokaryotes and eukaryotes;
Wang, Ping, Heitman, Joseph
openaire   +2 more sources

Analyses of the toxic properties of recombinant human Cyclophilin A in mice

Journal of Immunotoxicology, 2019
Cyclophilin A (CypA), an 18 kDa multi-functional protein with cis–trans isomerase activity, is both a ligand for cyclosporine A and a proinflammatory factor. CypA is also a chemoattractant for hemopoietic stem cells and progenitors of different lineages,
Anastasiya Kalinina, Mariya Zamkova, Elena Antoshina, Lubov Trukhanova, Tatyana Gorkova, Dmitriy Kazansky, Ludmila Khromykh   +6 more
doaj   +1 more source

Cyclophilin A induces macrophage apoptosis and enhances atherosclerotic lesions in high‐fat diet‐fed hyperglycemic rabbits

FASEB BioAdvances, 2021
Macrophage apoptosis is a key contributor to the progression of atherosclerosis. Cyclophilin A, a monocyte secretory protein associated with the initiation of atherosclerosis has an inherent nuclease activity.
Vinitha Anandan, Santhosh Kumar Thankayyan Retnabai, Abdul Jaleel, Thushara Thulaseedharan, Ajit Mullasari, M. Radhakrishna Pillai, Cheranellore Chandrasekharan Kartha, Surya Ramachandran   +7 more
doaj   +1 more source

Maternal and cord blood cyclophilin A in severe preeclampsia and normal pregnancy and its correlation with vitamin D and zinc

Hypertension in Pregnancy, 2017
Objective: To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level.
Noroyono Wibowo, Riyan Hari Kurniawan, Rima Irwinda, Natasya Prameswari   +3 more
doaj   +1 more source

Genome-wide identification and stress response analysis of cyclophilin gene family in apple (Malus × domestica)

BMC Genomics, 2022
Background Cyclophilin (CYP) belongs to the immunophilin family and has peptidyl-prolyl cis-trans isomerase (PPIase) activity, which catalyzes the cis-trans isomerization process of proline residues.
Zhi-Wen Qiao, Da-Ru Wang, Xun Wang, Chun-Xiang You, Xiao-Fei Wang   +4 more
doaj   +1 more source

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, EarlyView.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources

Cyclophilin A Impairs Efferocytosis and Accelerates Atherosclerosis by Overexpressing CD 47 and Down-Regulating Calreticulin

Cells, 2021
Impairment of efferocytosis in apoptotic macrophages is a known determinant of the severity of atherosclerosis and the vulnerability of plaques to rupture. The precise mechanisms involved in impaired efferocytosis are unclear.
Vinitha Anandan, Thushara Thulaseedharan, Aishwarya Suresh Kumar, Karthika Chandran Latha, Amjesh Revikumar, Ajit Mullasari, Chandrasekharan C. Kartha, Abdul Jaleel, Surya Ramachandran   +8 more
doaj   +1 more source

Study of Cyclophilin_ A in Egyptian Patients with Chronic Heart Failure Diseases [PDF]

Research Journal of Applied Biotechnology, 2022
Background. A Clinical phenomenon that has historically been categorized as a condition where the heart's ability to pump and fill with blood is diminished is known as a Heart failure (HF), which is still the world's number one cause of death.
Ahmed Hassanain, Mohamed Nasr, Randa Ghonoum, Sabah Farouk, Mohamed Abied   +4 more
doaj   +1 more source

Molecular Dynamic Simulation and Docking of Cyclophilin A Mutants with its Potential Inhibitors

Journal of Clinical and Basic Research, 2021
Background and objectives: Cyclophilin A (CypA) is involved in various human biological processes. Its role in many pathological conditions makes it a promising target for treating human diseases, such as viral infections.
Alireza Mohebbi, Azam Mirarab, Reyhane Shaddel, Mahnaz Shafaei Fallah, Ali Memarian   +4 more
doaj  

The Arabidopsis Cyclophilin Gene Family [PDF]

Plant Physiology, 2004
AbstractDatabase searching has allowed the identification of a number of previously unreported single and multidomain isoform members of the Arabidopsis cyclophilin gene family. In addition to the cyclophilin-like peptidyl-prolyl cis-trans isomerase domain, the latter contain a variety of other domains with characterized functions.
Patrick G N, Romano, Peter, Horton, Julie E, Gray   +2 more
openaire   +2 more sources