Results 51 to 60 of about 35,749 (233)

Cyclosporine A Regulates Influenza A Virus-induced Macrophages Polarization and Inflammatory Responses by Targeting Cyclophilin A

Frontiers in Immunology, 2022
Cyclosporine A (CsA) is an immunosuppressive drug that suppresses T cell responses and is broadly used in transplantation. Its immunosuppressive action is closely linked to its binding of cyclophilin A (CypA), which widely distributed in different cell ...
Xiaoyuan Bai, Xiaoyuan Bai, Wenxian Yang, Wenxian Yang, Heqiao Li, Heqiao Li, Yuna Zhao, Yuna Zhao, Wenhui Fan, He Zhang, Wenjun Liu, Wenjun Liu, Wenjun Liu, Wenjun Liu, Lei Sun, Lei Sun   +15 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Placental Cyclophilin A Expression in Pregnancies Complicated with Hypertension

, 2022
Introduction: Cyclophilin A was reported to be increased in the serum of mothers with preeclampsia, and is implicated in its pathogenesis. This study aimed to determine the expression of cyclophilin A in the placenta of mothers with and without ...
Azyani Yahaya, Tan, Geok Chin, Geok Chin Tan, Yin Ping Wong, Muaatamarulain Mustangin, Alfian, Nurwardah, Aizuddin, Azimatun Noor, Elia Shazniza Shaaya, Wong, Yin Ping, Yahaya, Azyani, Nurwardah Alfian, Azimatun Noor Aizuddin, Shaaya, Elia Shazniza, Mustangin, Muaatamarulain   +13 more
core   +1 more source

Prognosis of sepsis induced by cecal ligation and puncture in mice improved by anti-Clonorchis Sinensis cyclopholin a antibodies

Parasites & Vectors, 2015
Background Cyclophilin A (CyPA), a ubiquitously distributed intracellular protein, is thought to be one of the important inflammatory factors and plays a significant role in the development process of sepsis.
Tianzhang Song, Mei Yang, Jintao Chen, Lilin Huang, Hongling Yin, Tailong He, Huaiqiu Huang, Xuchu Hu   +7 more
doaj   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Evaluation of cardiac histology and cell death markers during the progression of diabetes in a streptozotocin‐induced diabetes rat model

Animal Models and Experimental Medicine, EarlyView.
Daily insulin administration in streptozotocin‐induced diabetic rats prevented cardiac damage associated with diabetic cardiomyopathy, including hypertrophy, fibrosis, and expression of cell death markers, at 12 weeks. However, cyclophilin D, a marker of mitochondrial permeability transition pore‐opening‐associated cell death (necrosis), was observed ...
Tamara Sáez, Ivo Carrasco‐Wong, Juan Varas, Sebastián San Martín, Jaime A. Riquelme, Rienzi Díaz‐Navarro   +5 more
wiley   +1 more source

Cyclophilin A Plays Potential Roles in a Rat Model of Asthma and Suppression of Immune Response

Journal of Asthma and Allergy, 2021
Cai-Tao Chen,1 Chun-Xiao Shan,2 Jun Ran,3 Lei-Miao Yin,1 Hai-Yan Li,4 Yu Wang,1 Yu-Dong Xu,1 Jing-Lei Guo,5 Yang-Lin Shi,1 Yan-Jiao Chen,1 Yong-Qing Yang1 1Shanghai Research Institute of Acupuncture and Meridian, Yueyang Hospital of Integrated ...
Chen CT, Shan CX, Ran J, Yin LM, Li HY, Wang Y, Xu YD, Guo JL, Shi YL, Chen YJ, Yang YQ   +10 more
doaj  

Cyclophilin Succumbs to a Macrocyclic Chameleon [PDF]

Journal of Medicinal Chemistry, 2018
Targets that have large and groove-shaped binding sites, such as cyclophilin, are difficult to drug with small molecules. Macrocycles of natural product origin can be ideal starting points for such targets as illustrated by the transformation of sanglifehrin A into an orally bioavailable potential candidate drug.
Bradley C. Doak, Jan Kihlberg
openaire   +2 more sources

Cyclophilin sequence analysis.

, 2012
(A) Neighbor-joining tree of putative cyclophilin L. longipalpis (RAAPBAR022E08/AM092289, male reproductive organs and whole female cDNA libraries), A. gambiae (AGAP007088-PA), A. aegypti (AAEL013279), D.
Glauber Wagner (173002), Nataly A. Souza (138702), Rodolpho M. Albano (172995), Denise B. S. Dias (172981), Renata V. D. M. Azevedo (172978), Alberto M. R. Davila (173010), Camila J. Mazzoni (172989), Alexandre A. Peixoto (138715), Jorge A. C. Bretãs (172984)   +8 more
core   +1 more source

Cyclophilin A and CD147: novel therapeutic targets for the treatment of COVID-19

Medicine in Drug Discovery, 2020
The outbreak of pneumonia caused by a new coronavirus (SARS-CoV-2) occurred in December 2019, and spread rapidly throughout the world. There have been other severe coronavirus outbreaks worldwide, namely, severe acute respiratory syndrome (SARS-CoV) and ...
Chenglong Liu, Albrecht von Brunn, Di Zhu   +2 more
doaj   +1 more source