Results 61 to 70 of about 31,837 (203)
Targeting KRAS for cancer therapy
British Journal of Pharmacology, EarlyView.In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia +4 more
wiley +1 more source
Daraxonrasib and Beyond: Pan‐RAS Inhibition, Resistance, and Next‐Generation Strategies
Cancer Science, EarlyView.ABSTRACT RAS proteins have long been considered difficult therapeutic targets, but allele‐selective inhibitors established the clinical tractability of mutant RAS. Daraxonrasib (RMC‐6236), an oral pan‐RAS inhibitor, has now extended this concept by targeting multiple mutant and wild‐type RAS proteins.
Ryo Honda
wiley +1 more source
EMBO ReportsCyclosporin A (CsA) induces DNA double-strand breaks in LIG4 syndrome fibroblasts, specifically upon transit through S-phase. The basis underlying this has not been described.
Marisa Bedir +5 more
doaj +1 more source
FEBS Open Bio, 2017 We have established a refined methodology for generating surface plasmon resonance sensor surfaces of recombinant his‐tagged human cyclophilin‐A. Our orientation‐specific stabilisation approach captures his‐tagged protein under ‘physiological conditions’
Martin A. Wear +4 more
doaj +1 more source
MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface
eLife, 2020 The type one interferon induced restriction factor Myxovirus resistance B (MxB) restricts HIV-1 nuclear entry evidenced by inhibition of 2-LTR but not linear forms of viral DNA.
Richard J Miles +5 more
doaj +1 more source
Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice
The FEBS Journal, EarlyView.Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan +8 more
wiley +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2020 Abdallah Mahmoud El-Ebidi,1 Tahia H Saleem,2 Mohamed Gamal El-din Saadi,3 Hala Abdallah Mahmoud,4 Zeinab Mohamed,5 Hoda S Sherkawy1 1Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Aswan University, Aswan, Egypt ...
El-Ebidi AM +5 more
doaj
Leaf Structure and Hormonal Balance Modulate Host‐Specificity and Pathogenicity of Botrytis cinerea
Plant, Cell &Environment, EarlyView.ABSTRACT Botrytis cinerea, a highly successful necrotrophic fungal plant pathogen, demonstrates a remarkably broad host range, yet the precise factors governing its host specificity and its ability to coexist non‐pathogenically with plants remain unclear. This study systematically assessed host preference in a series of B. cinerea agricultural isolates,
Gautam Anand +12 more
wiley +1 more source
Soluble expression of recombinant cyclophilin A in Escherichia coli
浙江大学学报. 农业与生命科学版, 2010 To produce a large amount of soluble cyclophilin A (CypA) protein, the recombinant pRSET -CypA plasmid was transferred into E. coli BL21. Using the 2×YT culture medium, the medium compositions of carbon source, nitrogen source and ampicillin ...
YAN Xiao +3 more
doaj +1 more source
Extracellular cyclophilins in health and disease
Biochimica et Biophysica Acta (BBA) - General Subjects, 2015 Extracellular cyclophilins (eCyPs) are pro-inflammatory factors implicated in pathogenesis of a number of inflammatory diseases. Most pathogenic activities of eCyPs are related to their chemotactic action towards leukocytes, which is mediated by eCyP receptor on target cells, CD147, and involves peptidyl-prolyl cis-trans isomerase activity of ...
openaire +2 more sources