Results 61 to 70 of about 35,749 (233)

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, EarlyView.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

S-cyclophilin. New member of the cyclophilin family associated with the secretory pathway

Journal of Biological Chemistry, 1991
Cyclophilin is an abundant and ubiquitous cytosolic protein that is conserved throughout evolution from man to bacteria. It is the target of the immunosuppressive drug cyclosporin A. Cyclophilin has peptidyl-prolyl cis/trans-isomerase activity, and it accelerates protein folding in vitro, suggesting that it might be involved in the folding of cytosolic
P, Caroni, A, Rothenfluh, E, McGlynn, C, Schneider   +3 more
openaire   +2 more sources

A cDNA Clone for Cyclophilin from Griffithsia japonica and Phylogenetic Analysis of Cyclophilins

Molecules and Cells, 2002
A cDNA clone, designated as Griffithsia japonica cyclophilin-1 (GjCyp-1), was isolated by differential screening of a cDNA library for a red alga, G. japonica. The transcript that corresponded to GjCyp-1 was abundant in vegetative, male, and tetrasporangial thalli, but only the basal level of the transcript was detected in female gametophytes ...
Yoo Kyung, Lee, Choo Bong, Hong, Youngbae, Suh, In Kyu, Lee   +3 more
openaire   +2 more sources

Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B

, 2011
Renal excretion of citrate, an inhibitor of calcium stone formation, is controlled mainly by reabsorption via the apical Na(+)-dicarboxylate cotransporter NaDC1 (SLC13A2) in the proximal tubule.
Gergely Kovacs, Marc Bürzle, Kovacs, Gergely, Alexandre Simonin, Bergeron, Marc J, Matthias A. Hediger, Hediger, Matthias A, Bürzle, Marc, Simonin, Alexandre, Marc J. Bergeron   +9 more
core   +1 more source

Improved Immuno-Detection of a Low-Abundance Cyclophilin Allows the Confirmation of its Expression in a Protozoan Parasite [PDF]

, 2015
Protein samples can be challenging to analyze due to the presence of high-abundance proteins masking low abundance proteins of interest, such as biomarkers and novel physiological mediators.
Perrone, Alina Elizabeth, Bustos, Patricia Laura, Bua, Jacqueline Elena, Milduberger, Natalia Ayelen   +3 more
core   +1 more source

Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation

Inflammation and Regeneration, 2023
Background Testosterone contributes to male organism development, such as bone density, muscle development, and fat repartition. Estrogen (derived from testosterone) also contributes to female reproductive system development.
Kouminin Kanwore, Konimpo Kanwore, Xiaoxiao Guo, Ying Xia, Han Zhou, Lin Zhang, Gabriel Komla Adzika, Adu-Amankwaah Joseph, Ayanlaja Abdulrahman Abiola, Peipei Mu, Piniel Alphayo Kambey, Marie Louis N’dzie Noah, DianShuai Gao   +12 more
doaj   +1 more source

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

ЦИКЛОФИЛИН А: СТРОЕНИЕ И ФУНКЦИИ

, 2017
Cyclophilins belong to a large family of ancient conservative proteins with peptidyl-prolyl-cis-trans isomerase activity. The main member of this family – cyclophilin A – was discovered as an intracellular ligand for cyclosporine A.
D. B. Kazansky, Л. М. Хромых, А. А. Калинина, Д. Б. Казанский, A. A. Kalinina, L. M. Khromykh   +5 more
core   +2 more sources

Rapid and efficient quality control analysis of isolated mitochondria by interferometric light microscopy

VIEW, EarlyView.
Mitochrial transplantation is a promising therapy to restore energy in damaged cells, but it lacks fast and reliable methods to assess mitochondrial quality before use. In this study, we used a label‐free imaging technique called interferometric light microscopy to rapidly measure the size and concentration of isolated mitochondria.
Sabah Mozafari, Christopher Ribes, Dmitry Ayollo, Florence Gazeau, Amanda K. A. Silva, Kelly Aubertin   +5 more
wiley   +1 more source

An endoplasmic reticulum-specific cyclophilin. [PDF]

Molecular and Cellular Biology, 1991
Cyclophilin is a ubiquitously expressed cytosolic peptidyl-prolyl cis-trans isomerase that is inhibited by the immunosuppressive drug cyclosporin A. A degenerate oligonucleotide based on a conserved cyclophilin sequence was used to isolate cDNA clones representing a ubiquitously expressed mRNA from mice and humans.
K W, Hasel, J R, Glass, M, Godbout, J G, Sutcliffe   +3 more
openaire   +2 more sources