Results 81 to 90 of about 32,096 (206)

Extracellular cyclophilins in health and disease

Biochimica et Biophysica Acta (BBA) - General Subjects, 2015
Extracellular cyclophilins (eCyPs) are pro-inflammatory factors implicated in pathogenesis of a number of inflammatory diseases. Most pathogenic activities of eCyPs are related to their chemotactic action towards leukocytes, which is mediated by eCyP receptor on target cells, CD147, and involves peptidyl-prolyl cis-trans isomerase activity of ...
openaire   +2 more sources

Leaf Structure and Hormonal Balance Modulate Host‐Specificity and Pathogenicity of Botrytis cinerea

Plant, Cell &Environment, EarlyView.
ABSTRACT Botrytis cinerea, a highly successful necrotrophic fungal plant pathogen, demonstrates a remarkably broad host range, yet the precise factors governing its host specificity and its ability to coexist non‐pathogenically with plants remain unclear. This study systematically assessed host preference in a series of B. cinerea agricultural isolates,
Gautam Anand, Chen Benoni, Meirav Leibman‐Markus, Rupali Gupta, Iftah Marash, Loida Tejada, Tali Dolgov, Dalia Rav‐David, Ondřej Plíhal, Ondřej Novák, Maya Kleiman, Yigal Elad, Maya Bar   +12 more
wiley   +1 more source

Unlocking the Door to Neuronal Woes in Alzheimer’s Disease: Aβ and Mitochondrial Permeability Transition Pore

Pharmaceuticals, 2010
Mitochondrial dysfunction occurs early in the progression of Alzheimer’s disease. Amyloid-β peptide has deleterious effects on mitochondrial function and contributes to energy failure, respiratory chain impairment, neuronal apoptosis, and generation of ...
Heng Du, Shirley ShiDu Yan
doaj   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Study of Cyclophilin A Polymorphism in Women Patients with Cytomegalovirus Infections

Medical Journal of Babylon
Background: Cyclophilin A (CypA) is a highly conserved protein that is expressed in a wide range of tissues and cell types and plays roles in inflammation, oxidative stress, and viral infection.
Hawraa Ahmed Ali, Mohammed Sabri Abdul-Razzag, Milal Muhammad Al-Jeborry   +2 more
doaj   +1 more source

Insights into the Roles of Cyclophilin A During Influenza Virus Infection

Viruses, 2013
Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the
Wenjun Liu, Zhendong Zhao, Xiaoling Liu
doaj   +1 more source

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

The Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin, Andrea Carrer, Federica Boscolo Nata, Elena Frigo, Federico Fogolari, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +7 more
wiley   +1 more source

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi, Caterina Miro, Annunziata Gaetana Cicatiello, Ilaria Piccialli, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Rosa Sirica, Melania Murolo, Emery Di Cicco, Daniela Terracciano, Anna Pannaccione, Monica Dentice   +12 more
wiley   +1 more source

Phenotypic expression of the gene‐for‐gene interaction in plant pathogenic bacteria: An implication for resistance to bacterial diseases by plants

Agrosystems, Geosciences &Environment, Volume 9, Issue 3, September 2026.
Abstract Plant pathogenic bacteria cause massive losses in agriculture and damage to natural plant habitats. Bacterial pathogens not only reduce crop production, but they also reduce crop quality by releasing toxins into the environment. Pathogenic bacteria that invade plant tissues must overcome the plant's defense mechanisms. Plants possess an innate
Muluken Getahun, Zelalem Bekeko
wiley   +1 more source