Results 81 to 90 of about 35,749 (233)
Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice
The FEBS Journal, EarlyView.Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan +8 more
wiley +1 more source
Cyclophilin Content of Normal and Psoriatic Epidermis
, 1990 The unique, immunosuppressive agent cyclosporine A has been shown to be of important therapeutic value in the treatment of psoriasis and other inflammatory dermatoses. To investigate the basis for its therapeutic efficacy, the tissue and cellular content
John J. Voorhees +9 more
core +1 more source
Cyclophilin D as a potential target for antioxidants in neurodegeneration: the X-ALD case [PDF]
, 2020 : X-linked adrenoleukodystrophy (X-ALD) is a severe inherited neurodegenerative disorder characterized by adrenal insufficiency and graded damage in the nervous system.
Pujol Onofre, Aurora +3 more
core +1 more source
Evolving treatments for Sjögren disease: current approaches and emerging targets
Internal Medicine Journal, EarlyView.Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani +3 more
wiley +1 more source
Extracellular cyclophilins in health and disease
Biochimica et Biophysica Acta (BBA) - General Subjects, 2015 Extracellular cyclophilins (eCyPs) are pro-inflammatory factors implicated in pathogenesis of a number of inflammatory diseases. Most pathogenic activities of eCyPs are related to their chemotactic action towards leukocytes, which is mediated by eCyP receptor on target cells, CD147, and involves peptidyl-prolyl cis-trans isomerase activity of ...
openaire +2 more sources
Cyclophilins: Proteins in search of function [PDF]
Plant Signaling & Behavior, 2013 Cyclophilins constitute a subgroup of large family of proteins called immunophilins, which also include FKBPs and Parvulins. They are remarkably conserved in all genera, highlighting their pivotal role in important cellular processes. Most cyclophilins display PPIase enzymatic activity, multiplicity, diverse cellular locations and active role in ...
Kumari, Sumita +4 more
openaire +2 more sources
EMBO ReportsCyclosporin A (CsA) induces DNA double-strand breaks in LIG4 syndrome fibroblasts, specifically upon transit through S-phase. The basis underlying this has not been described.
Marisa Bedir +5 more
doaj +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2020 Abdallah Mahmoud El-Ebidi,1 Tahia H Saleem,2 Mohamed Gamal El-din Saadi,3 Hala Abdallah Mahmoud,4 Zeinab Mohamed,5 Hoda S Sherkawy1 1Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Aswan University, Aswan, Egypt ...
El-Ebidi AM +5 more
doaj
MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface
eLife, 2020 The type one interferon induced restriction factor Myxovirus resistance B (MxB) restricts HIV-1 nuclear entry evidenced by inhibition of 2-LTR but not linear forms of viral DNA.
Richard J Miles +5 more
doaj +1 more source
Immunology, EarlyView.Calcium oxalate monohydrate (COM) crystals cause changes in the secretion of 29 proteins from neutrophil‐like cells, including those involved in neutrophil immune activation and intracellular metabolic adaptation. The neutrophil secreted proteins (secretome) also inhibit calcium oxalate crystallisation and crystal growth, but promote crystal ...
Chanettee Lertprapai +2 more
wiley +1 more source