Cyclophilin B serum levels present variations across the menstrual cycle [PDF]
Scientific Reports, 2023 Cyclophilins are a family of chaperones involved in inflammation and cell death. Cyclophilin B is released by inflammatory cells and acts through the receptor CD147, affecting matrix metalloproteases release, whilst cyclophilin D participates in hypoxia ...
Rebeca Alvariño +7 more
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Accelerated Aging in Cyclophilin B–Deficient Mice Downstream of p21‐Cip1/Waf1 [PDF]
JBMR Plus, 2022 Loss of bone mass and strength is a common problem of advanced age in humans. Defective bone is also a primary finding in osteogenesis imperfecta (OI), a genetic condition most commonly caused by autosomal dominant mutations in the type I collagen genes.
Ying Zhang +2 more
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Cyclophilin B facilitates the replication of Orf virus [PDF]
Virology Journal, 2017 Background Viruses interact with host cellular factors to construct a more favourable environment for their efficient replication. Expression of cyclophilin B (CypB), a cellular peptidyl-prolyl cis-trans isomerase (PPIase), was found to be significantly ...
Kui Zhao +7 more
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Sanglifehrin A mitigates multiorgan fibrosis by targeting the collagen chaperone cyclophilin B [PDF]
JCI InsightPathological deposition and crosslinking of collagen type I by activated myofibroblasts drives progressive tissue fibrosis. Therapies that inhibit collagen synthesis have potential as antifibrotic agents.
Hope A. Flaxman +13 more
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Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model. [PDF]
PLoS ONECyclophilins are a diverse family of peptidyl-prolyl isomerases (PPIases) of importance in a variety of essential cellular functions. We previously reported that the pan-cyclophilin inhibitor drug reconfilstat (CRV431) decreased disease in mice under the
Winston T Stauffer +5 more
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Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum [PDF]
Nature Communications, 2017 Invasion of red blood cells by Plasmodium falciparum is a complex process and relies on several receptor-ligand interactions. Here, the authors show that human cyclophilin B binds Plasmodium surface protein PfRhopH3 and that interruption of this ...
Prem Prakash +18 more
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Elevated Serum Cyclophilin B Levels Are Associated with the Prevalence and Severity of Metabolic Syndrome [PDF]
Frontiers in Endocrinology, 2017 ObjectiveInflammation plays a central role in the pathogenesis of metabolic syndrome (MetS). Cyclophilin B (CypB) can be constitutively secreted in response to inflammatory stimuli and oxidative stress, participating in tissue or systemic inflammation ...
Hang Zhang +16 more
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High-fat diet induced cyclophilin B enhances STAT3/lncRNA-PVT1 feedforward loop and promotes growth and metastasis in colorectal cancer [PDF]
Cell Death and Disease, 2022 High-fat diet (HFD) has been implicated to promote colorectal cancer (CRC). Recently, oncogene Cyclophilin B (CypB) is reported to be induced by cholesterol.
Hanqing Guo +8 more
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Cyclophilin B control of lysine post-translational modifications of skin type I collagen. [PDF]
PLoS Genetics, 2019 Covalent intermolecular cross-linking of collagen is essential for tissue stability. Recent studies have demonstrated that cyclophilin B (CypB), an endoplasmic reticulum (ER)-resident peptidyl-prolyl cis-trans isomerase, modulates lysine (Lys ...
Masahiko Terajima +13 more
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Implication of the whitefly Bemisia tabaci Cyclophilin B protein in the transmission of Tomato yellow leaf curl virus [PDF]
Frontiers in Plant Science, 2016 Tomato yellow leaf curl virus (TYLCV) is a single-stranded (ssDNA) begomoviruses that causes severe damage to tomato and several other crops worldwide.
Surapathrudu Kanakala, Murad Ghanim
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