Cyclophilin B serum levels present variations across the menstrual cycle [PDF]
Scientific Reports, 2023 Cyclophilins are a family of chaperones involved in inflammation and cell death. Cyclophilin B is released by inflammatory cells and acts through the receptor CD147, affecting matrix metalloproteases release, whilst cyclophilin D participates in hypoxia ...
Rebeca Alvariño +7 more
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Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model. [PDF]
PLoS ONECyclophilins are a diverse family of peptidyl-prolyl isomerases (PPIases) of importance in a variety of essential cellular functions. We previously reported that the pan-cyclophilin inhibitor drug reconfilstat (CRV431) decreased disease in mice under the
Winston T Stauffer +5 more
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Sanglifehrin A mitigates multiorgan fibrosis by targeting the collagen chaperone cyclophilin B [PDF]
JCI InsightPathological deposition and crosslinking of collagen type I by activated myofibroblasts drives progressive tissue fibrosis. Therapies that inhibit collagen synthesis have potential as antifibrotic agents.
Hope A. Flaxman +13 more
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Cyclophilin B facilitates the replication of Orf virus [PDF]
Virology Journal, 2017 Background Viruses interact with host cellular factors to construct a more favourable environment for their efficient replication. Expression of cyclophilin B (CypB), a cellular peptidyl-prolyl cis-trans isomerase (PPIase), was found to be significantly ...
Kui Zhao +7 more
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Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum [PDF]
Nature Communications, 2017 Invasion of red blood cells by Plasmodium falciparum is a complex process and relies on several receptor-ligand interactions. Here, the authors show that human cyclophilin B binds Plasmodium surface protein PfRhopH3 and that interruption of this ...
Prem Prakash +18 more
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Accelerated Aging in Cyclophilin B–Deficient Mice Downstream of p21‐Cip1/Waf1 [PDF]
JBMR Plus, 2022 Loss of bone mass and strength is a common problem of advanced age in humans. Defective bone is also a primary finding in osteogenesis imperfecta (OI), a genetic condition most commonly caused by autosomal dominant mutations in the type I collagen genes.
Ying Zhang +2 more
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Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B. [PDF]
J Gen Virol, 2017 Feline coronavirus (FCoV) causes the fatal disease feline infectious peritonitis, which is currently incurable by drug treatment, and no effective vaccines are available. Cyclosporin A (CsA), a cyclophilin (Cyp) inhibitor, inhibits the replication of FCoV in vitro and in vivo as well as the replication of human and animal coronaviruses.
Tanaka Y, Sato Y, Sasaki T.
europepmc +3 more sources
Cyclophilin B enhances HIV-1 infection. [PDF]
Virology, 2016 Cyclophilin B (CypB) is a member of the immunophilin family and intracellular chaperone. It predominantly localizes to the ER, but also contains a nuclear localization signal and is secreted from cells. CypB has been shown to interact with the Gag protein of human immunodeficiency type 1 (HIV-1). Several proteomic and genetic studies identified it as a
DeBoer J, Madson CJ, Belshan M.
europepmc +3 more sources
Severe osteogenesis imperfecta in cyclophilin B-deficient mice. [PDF]
PLoS Genetics, 2009 Osteogenesis Imperfecta (OI) is a human syndrome characterized by exquisitely fragile bones due to osteoporosis. The majority of autosomal dominant OI cases result from point or splice site mutations in the type I collagen genes, which are thought to ...
Jae Won Choi +8 more
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High-fat diet induced cyclophilin B enhances STAT3/lncRNA-PVT1 feedforward loop and promotes growth and metastasis in colorectal cancer [PDF]
Cell Death and Disease, 2022 High-fat diet (HFD) has been implicated to promote colorectal cancer (CRC). Recently, oncogene Cyclophilin B (CypB) is reported to be induced by cholesterol.
Hanqing Guo +8 more
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