Results 21 to 30 of about 31,607 (207)

Cyclophilin A facilitates influenza B virus replication by stabilizing viral proteins

iScience, 2023
Summary: Influenza B circulates annually and causes substantial disease burden in humans. However, little is known about the infection mechanisms of influenza B virus (IBV).
Huizi Li, Wenhui Fan, Jie Min, Xiaoyuan Bai, Wenxian Yang, Heqiao Li, Yuna Zhao, Runshan Lin, Xiaojuan Jia, Wenjun Liu, Lei Sun   +10 more
doaj   +3 more sources

NMR studies of [U‐¹³C]cyclosporin A bound to human cyclophilin B [PDF]

FEBS Letters, 1991
NMR data (1H and 13C chemical shifts, NOEs) on [[U‐13C]cyclosporin A bound to cyclophilin B were compared to previously published data on the [U‐13C]CsA/CyPA complex [Fesik et al., (1991) Biochemistry 30, 6574–6583]. Despite only 64% sequence identity between CyPA and CyPB, the conformation and active site environment of CsA when bound to CyPA and CyPB
NERI, Placido, G. Gemmecker, L. D. Zydowsky, C. T. Walsh, S. W. Fesik   +4 more
openaire   +4 more sources

Cyclophilin B is really a major growth factor in breast milk. [PDF]

J Biol Chem, 2022
Delmas O.
europepmc   +4 more sources

Experimental and MEDT Study of Sydnone–Alkyne Cycloaddition-Based Synthesis of 1,4-Disubstituted Pyrazoles and In Silico Investigation of Their Binding to HCV and HIV Proteins [PDF]

Molecules
Six 1,4-disubstituted pyrazoles linked to a benzenesulfonamide and a benzodioxane unit have been synthesized through a copper(I)-catalyzed formal [3+2] cycloaddition (32CA) reaction of alkynes with 3-arylsydnones.
Souad Zerbib, Mohammed Eddahmi, Marwa Alaqarbeh, Pierre-Edouard Bodet, Valérie Thiery, Ahmed Fatimi, Natália Cruz-Martins, Christian Bailly, Luis R. Domingo, Latifa Bouissane   +9 more
doaj   +2 more sources

Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections

Viruses
Cyclophilin (Cyp) inhibitors are of clinical interest in respect to their antiviral activities in the context of many viral infections including chronic hepatitis B and C.
Jennifer Molle, Sarah Duponchel, Jennifer Rieusset, Michel Ovize, Alexander V. Ivanov, Fabien Zoulim, Birke Bartosch   +6 more
doaj   +4 more sources

Optimization of Cyclophilin B-Targeted Tri-vector Inhibitors for Novel MASH Treatments. [PDF]

J Med Chem
Cyclophilins have been implicated in the pathophysiology of metabolic dysfunction-associated steatohepatitis (MASH).Pharmacological inhibition of the cyclophilin B isoform has the potential to attenuate liver fibrosis in MASH, but current cyclophilin ...
Kouridaki ME, Gillespie J, Robinson J, Mathie T, Bain L, McArthur D, Morrison A, Greenslade DB, Papadourakis M, Maj K, Cameron K, Turner D, Webster SP, Wear MA, Doughty-Shenton D, Hulme AN, Michel J.   +16 more
europepmc   +3 more sources

Association of cyclophilins and cardiovascular risk factors in coronary artery disease

Frontiers in Physiology, 2023
Cyclophilins are chaperone proteins that play important roles in signal transduction. Among them, cyclophilins A, B, C, and D were widely associated with inflammation and cardiovascular diseases. Cyclophilins A and C have been proposed as coronary artery
Sandra Gegunde, Sandra Gegunde, Amparo Alfonso, Amparo Alfonso, Rebeca Alvariño, Rebeca Alvariño, Nadia Pérez-Fuentes, Nadia Pérez-Fuentes, Jeremías Bayón-Lorenzo, Jeremías Bayón-Lorenzo, Eva Alonso, Eva Alonso, Raymundo Ocaranza-Sánchez, Raymundo Ocaranza-Sánchez, Rosa Alba Abellás-Sequeiros, Rosa Alba Abellás-Sequeiros, Melisa Santás-Álvarez, Melisa Santás-Álvarez, Mercedes R. Vieytes, Carlos Juanatey-González, Carlos Juanatey-González, Luis M. Botana, Luis M. Botana   +22 more
doaj   +1 more source

Extracellular cyclophilins A and C induce dysfunction of pancreatic microendothelial cells

Frontiers in Physiology, 2022
Extracellular cyclophilins (eCyps) A and B are chemotactic mediators in several illnesses in which inflammation plays an important role such as diabetes and cardiovascular diseases.
Rebeca Alvariño, Rebeca Alvariño, Amparo Alfonso, Amparo Alfonso, Nadia Pérez-Fuentes, Nadia Pérez-Fuentes, Jesús M. González-Jartín, Jesús M. González-Jartín, Sandra Gegunde, Sandra Gegunde, Sandra Gegunde, Mercedes R. Vieytes, Mercedes R. Vieytes, Luis M. Botana, Luis M. Botana   +14 more
doaj   +1 more source

Delineation of the calcineurin‐interacting region of cyclophilin B [PDF]

Protein Science, 2000
AbstractThe immunosuppressant drug cyclosporin A (CsA) inhibits T‐cell function by blocking the phosphatase activity of calcineurin. This effect is mediated by formation of a complex between the drug and cyclophilin (CyP), which creates a composite surface able to make high‐affinity contacts with calcineurin.
M, Carpentier, F, Allain, B, Haendler, M C, Slomianny, G, Spik   +4 more
openaire   +2 more sources

Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1). [PDF]

Int J Mol Sci, 2019
Of the three interleukin-22 binding protein (IL-22BP) isoforms produced by the human IL22RA2 gene, IL-22BPi2 and IL-22BPi3 are capable of neutralizing IL-22.
Gómez-Fernández P, Urtasun A, Astobiza I, Mena J, Alloza I, Vandenbroeck K.   +5 more
europepmc   +2 more sources