Severe osteogenesis imperfecta in cyclophilin B-deficient mice. [PDF]
PLoS Genetics, 2009 Osteogenesis Imperfecta (OI) is a human syndrome characterized by exquisitely fragile bones due to osteoporosis. The majority of autosomal dominant OI cases result from point or splice site mutations in the type I collagen genes, which are thought to ...
Jae Won Choi +8 more
doaj +5 more sources
Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models [PDF]
BMC MedicineBackground Heart failure (HF) represents the end stage of cardiovascular diseases with high mortality and limited treatment options. Cyclophilin B (CypB), known mainly as an endoplasmic reticulum chaperone, has been implicated in cardiovascular diseases.
Xiao Zong +6 more
doaj +2 more sources
Plant-Mediated Silencing of the Whitefly Bemisia tabaci Cyclophilin B and Heat Shock Protein 70 Impairs Insect Development and Virus Transmission [PDF]
Frontiers in Physiology, 2019 The whitefly B. tabaci is a global pest and transmits extremely important plant viruses especially begomoviruses, that cause substantial crop losses. B.
Surapathrudu Kanakala +3 more
doaj +2 more sources
Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation. [PDF]
PLoS ONE, 2010 Peptidyl-prolyl cis/trans isomerases (PPIs) catalyze cis/trans isomerization of peptide bonds preceding proline residues. The involvement of PPI family members in protein refolding has been established in test tube experiments.
Riccardo Bernasconi +5 more
doaj +6 more sources
Cyclophilin A facilitates influenza B virus replication by stabilizing viral proteins
iScience, 2023 Summary: Influenza B circulates annually and causes substantial disease burden in humans. However, little is known about the infection mechanisms of influenza B virus (IBV).
Huizi Li +10 more
doaj +3 more sources
Experimental and MEDT Study of Sydnone–Alkyne Cycloaddition-Based Synthesis of 1,4-Disubstituted Pyrazoles and In Silico Investigation of Their Binding to HCV and HIV Proteins [PDF]
MoleculesSix 1,4-disubstituted pyrazoles linked to a benzenesulfonamide and a benzodioxane unit have been synthesized through a copper(I)-catalyzed formal [3+2] cycloaddition (32CA) reaction of alkynes with 3-arylsydnones.
Souad Zerbib +9 more
doaj +2 more sources
Cyclophilin B is really a major growth factor in breast milk. [PDF]
J Biol Chem, 2022 Delmas O.
europepmc +4 more sources
Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B. [PDF]
J Gen Virol, 2017 Feline coronavirus (FCoV) causes the fatal disease feline infectious peritonitis, which is currently incurable by drug treatment, and no effective vaccines are available. Cyclosporin A (CsA), a cyclophilin (Cyp) inhibitor, inhibits the replication of FCoV in vitro and in vivo as well as the replication of human and animal coronaviruses.
Tanaka Y, Sato Y, Sasaki T.
europepmc +3 more sources
Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections
VirusesCyclophilin (Cyp) inhibitors are of clinical interest in respect to their antiviral activities in the context of many viral infections including chronic hepatitis B and C.
Jennifer Molle +6 more
doaj +4 more sources
Cyclophilin B enhances HIV-1 infection. [PDF]
Virology, 2016 Cyclophilin B (CypB) is a member of the immunophilin family and intracellular chaperone. It predominantly localizes to the ER, but also contains a nuclear localization signal and is secreted from cells. CypB has been shown to interact with the Gag protein of human immunodeficiency type 1 (HIV-1). Several proteomic and genetic studies identified it as a
DeBoer J, Madson CJ, Belshan M.
europepmc +3 more sources