Results 41 to 50 of about 31,607 (207)

Cyclophilin B enhances the proliferation and differentiation of MC3T3-E1 cells via JAK2/STAT3 signaling pathway

open access: yesBiotechnology & Biotechnological Equipment, 2019
The aim of this study was to investigate the effects of cyclophilin B on MC3T3-E1 cells and the underlying mechanism. CCK-8 assay was used to evaluate the cell activity, polymerase chain reaction to verify the overexpression of cyclophilin B, western ...
Fan Mei, Yanhong Tu
doaj   +1 more source

A vaccine to prevent initial loss of cognition and eventual Alzheimer's disease in elderly persons

open access: yesAlzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Prevention is better than cure and prevention of Alzheimer's disease (AD) may be possible. In elderly persons who are cognitively normal, synaptic hypometabolism as shown by reduced cerebral uptake of fluorodeoxyglucose (18F‐FDG), provides a premonitory ...
Jeffrey Fessel
doaj   +1 more source

Role of Cyclophilin B in Prolactin Signal Transduction and Nuclear Retrotranslocation [PDF]

open access: yesMolecular Endocrinology, 2000
The pleiotropic actions of PRL are necessary for mammary growth and differentiation and in vitro lymphoid proliferation. The proximal action of this ligand is mediated by its cell surface receptor via associated networks. PRL action, however, is also associated with the internalization and translocation of this hormone into the nucleus.
M A, Rycyzyn   +3 more
openaire   +2 more sources

Differential expression of gut protein genes and population density of Arsenophonus contributes to sex-biased transmission of Bemisia tabaci vectored Cotton leaf curl virus.

open access: yesPLoS ONE, 2021
Whitefly, Bemisia tabaci (Gennadius) is an important pest of cotton causing direct damage as sap feeder and vector of Cotton leaf curl virus (CLCuV). Previous few studies suggest that female whiteflies are more efficient vector of begomovirusthan males ...
Ikbalpreet Singh   +4 more
doaj   +1 more source

Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A.

open access: yesPLoS ONE, 2010
BackgroundHepatitis C Virus (HCV) infection is a leading indication for liver transplantation. HCV infection reoccurs almost universally post transplant, decreasing both graft longevity and patient survival.
Fiona Fernandes   +2 more
doaj   +1 more source

SIV replication in human cells

open access: yesFrontiers in Microbiology, 2012
Current human immunodeficiency virus type 1 (HIV-1) pandemic is believed to originate from cross-species transmission of simian immunodeficiency virus (SIV) into human population.
Hiroaki eTakeuchi, Ryuta eSakuma
doaj   +1 more source

Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication

open access: yesRetrovirology, 2012
Background An understanding of host cell factors that affect viral replication contributes to elucidation of the mechanism for determination of viral tropism.
Takeuchi Hiroaki   +5 more
doaj   +1 more source

Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1991
We report the cloning and characterization of a cDNA encoding a second human cyclosporin A-binding protein (hCyPB). Homology analyses reveal that hCyPB is a member of the cyclophilin B (CyPB) family, which includes yeast CyPB, Drosophila nina A, and rat cyclophilin-like protein.
E R, Price   +5 more
openaire   +2 more sources

Cyclophilin B Expression in Renal Proximal Tubules of Hypertensive Rats [PDF]

open access: yesHypertension, 2000
Abstract —Rat cyclophilin-like protein (Cy-LP) is a candidate hypertension gene initially identified by differential hybridization and implicated in renal mechanisms of salt retention and high blood pressure. We report the molecular characterization of rat cyclophilin B (CypB) and demonstrate, through sequence analysis and
D B, Kainer, P A, Doris
openaire   +2 more sources

Furanoditerpenes from Spongia (Spongia) tubulifera Display Mitochondrial-Mediated Neuroprotective Effects by Targeting Cyclophilin D [PDF]

open access: yes, 2022
Neuroprotective properties of five previously described furanoditerpenes 1–5, isolated from Spongia (Spongia) tubulifera, were evaluated in an in vitro oxidative stress model in SH-SY5Y cells.
Luis M. Botana (1584997)   +7 more
core   +2 more sources

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