Results 41 to 50 of about 30,484 (184)

Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication

Retrovirology, 2012
Background An understanding of host cell factors that affect viral replication contributes to elucidation of the mechanism for determination of viral tropism.
Takeuchi Hiroaki, Ishii Hiroshi, Kuwano Tetsuya, Inagaki Natsuko, Akari Hirofumi, Matano Tetsuro   +5 more
doaj   +1 more source

Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. [PDF]

Proceedings of the National Academy of Sciences, 1991
We report the cloning and characterization of a cDNA encoding a second human cyclosporin A-binding protein (hCyPB). Homology analyses reveal that hCyPB is a member of the cyclophilin B (CyPB) family, which includes yeast CyPB, Drosophila nina A, and rat cyclophilin-like protein.
E R, Price, L D, Zydowsky, M J, Jin, C H, Baker, F D, McKeon, C T, Walsh   +5 more
openaire   +2 more sources

Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides

Angewandte Chemie, EarlyView.
Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi, Mariko Akiba, Marin Yokomine, Masatake Sugita, Koji Umezawa, Yuto Hirota, Yutaka Akiyama, Jumpei Morimoto, Shinsuke Sando   +8 more
wiley   +2 more sources

Cyclophilin B Expression in Renal Proximal Tubules of Hypertensive Rats [PDF]

Hypertension, 2000
Abstract —Rat cyclophilin-like protein (Cy-LP) is a candidate hypertension gene initially identified by differential hybridization and implicated in renal mechanisms of salt retention and high blood pressure. We report the molecular characterization of rat cyclophilin B (CypB) and demonstrate, through sequence analysis and
D B, Kainer, P A, Doris
openaire   +2 more sources

Involvement of cyclophilin B in the replication of Japanese encephalitis virus

Virology, 2011
Japanese encephalitis virus (JEV) is a mosquito-borne RNA virus that belongs to the Flaviviridae family. In this study, we have examined the effect of cyclosporin A (CsA) on the propagation of JEV. CsA exhibited potent anti-JEV activity in various mammalian cell lines through the inhibition of CypB.
Kambara, Hiroto, Tani, Hideki, Mori, Yoshio, Abe, Takayuki, Katoh, Hiroshi, Fukuhara, Takasuke, Taguwa, Shuhei, Moriishi, Kohji, Matsuura, Yoshiharu   +8 more
openaire   +2 more sources

Proteomic Alterations in B Lymphocytes of Sensitized Mice in a Model of Chemical-Induced Asthma. [PDF]

PLoS ONE, 2015
The role of B-lymphocytes in chemical-induced asthma is largely unknown. Recent work demonstrated that transferring B lymphocytes from toluene diisocyanate (TDI)-sensitized mice into naïve mice, B cell KO mice and SCID mice, triggered an asthma-like ...
Steven Haenen, Jeroen A J Vanoirbeek, Vanessa De Vooght, Liliane Schoofs, Benoit Nemery, Elke Clynen, Peter H M Hoet   +6 more
doaj   +1 more source

Role of Cyclophilin B in Activation of Interferon Regulatory Factor-3 [PDF]

Journal of Biological Chemistry, 2005
IRF-3 is a member of the interferon regulatory factors (IRFs) and plays a principal role in the induction of interferon-beta (IFN-beta) by virus infection. Virus infection results in the phosphorylation of IRF-3 by IkappaB kinase epsilon and TANK-binding kinase 1, leading to its dimerization and association with the coactivators CREB-binding protein ...
Yoko, Obata, Kazuo, Yamamoto, Masanobu, Miyazaki, Kunitada, Shimotohno, Shigeru, Kohno, Toshifumi, Matsuyama   +5 more
openaire   +2 more sources

Lack of Cyclophilin B in Osteogenesis Imperfecta with Normal Collagen Folding [PDF]

New England Journal of Medicine, 2010
Osteogenesis imperfecta is a heritable disorder that causes bone fragility. Mutations in type I collagen result in autosomal dominant osteogenesis imperfecta, whereas mutations in either of two components of the collagen prolyl 3-hydroxylation complex (cartilage-associated protein [CRTAP] and prolyl 3-hydroxylase 1 [P3H1]) cause autosomal recessive ...
Aileen M, Barnes, Erin M, Carter, Wayne A, Cabral, MaryAnn, Weis, Weizhong, Chang, Elena, Makareeva, Sergey, Leikin, Charles N, Rotimi, David R, Eyre, Cathleen L, Raggio, Joan C, Marini   +10 more
openaire   +2 more sources

Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype [PDF]

Journal of Molecular Cell Biology, 2020
Abstract Restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial–mesenchymal transition (pEMT), proliferation, and further redifferentiation into specialized tubule epithelial cells (TECs).
Eduard Sarró, Mónica Durán, Ana Rico, Diana Bou-Teen, Vanesa Fernández-Majada, Anthony J Croatt, Karl A Nath, Maria Teresa Salcedo, Justin H Gundelach, Daniel Batlle, Richard J Bram, Anna Meseguer   +11 more
openaire   +4 more sources

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source