Results 61 to 70 of about 31,607 (207)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B

, 2011
Renal excretion of citrate, an inhibitor of calcium stone formation, is controlled mainly by reabsorption via the apical Na(+)-dicarboxylate cotransporter NaDC1 (SLC13A2) in the proximal tubule.
Gergely Kovacs, Marc Bürzle, Kovacs, Gergely, Alexandre Simonin, Bergeron, Marc J, Matthias A. Hediger, Hediger, Matthias A, Bürzle, Marc, Simonin, Alexandre, Marc J. Bergeron   +9 more
core   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Schweizer Warmblutfohlen mit Symptomen von hereditärer dermaler Asthenie (HERDA) ohne Mutation im Cyclophilin B-Gen (PPIB)

, 2010
Hereditäre equine dermale Asthenie (HERDA) ist eine autosomal rezessive Hautkrankheit, die vor allem junge Quarter Horses und verwandte Rassen betrifft.
Winand, N., Straub, R, Steinmann, B, Stoffel, M H, Roosje, Petra, Rüfenacht, S, Wyder, M, Müller, Eliane, Stoffel, Michael Hubert, Bidaut, A, Gerber, V, Wyder, Marianne, Steinmann, B., Winand, N, Bidaut, A., Rüfenacht, Silvia, Müller, E, Straub, Reto, Gerber, Vinzenz, Roosje, P J   +19 more
core   +1 more source

Cyclophilin Inhibitor Rencofilstat Combined with Proteasome Inhibitor Ixazomib Increases Proteotoxic Cell Death in Advanced Prostate Cancer Cells with Minimal Effects on Non-Cancer Cells

Biomedicines
Background/Objective: Proteotoxic stress induced by inhibitors of the ubiquitin–proteasome system has been successful in multiple myeloma but not in solid cancers such as prostate cancer.
Carlos Perez-Stable, Alicia de las Pozas, Medhi Wangpaichitr, Robert T. Foster, Daren R. Ure   +4 more
doaj   +1 more source

Echinococcus granulosus cyclophilin: Immunoinformatics analysis to provide insights into the biochemical properties and immunogenic epitopes

Informatics in Medicine Unlocked, 2022
Vaccination is a prominent strategy to confine cystic echinococcosis (CE) in areas of endemicity worldwide. The present study was performed to predict the primary biochemical features and immunogenic epitopes of Echinococcus granulosus cyclophilin ...
Sasan Khazaei, Zeinab Moghadamizad
doaj   +1 more source

Evaluation of cardiac histology and cell death markers during the progression of diabetes in a streptozotocin‐induced diabetes rat model

Animal Models and Experimental Medicine, EarlyView.
Daily insulin administration in streptozotocin‐induced diabetic rats prevented cardiac damage associated with diabetic cardiomyopathy, including hypertrophy, fibrosis, and expression of cell death markers, at 12 weeks. However, cyclophilin D, a marker of mitochondrial permeability transition pore‐opening‐associated cell death (necrosis), was observed ...
Tamara Sáez, Ivo Carrasco‐Wong, Juan Varas, Sebastián San Martín, Jaime A. Riquelme, Rienzi Díaz‐Navarro   +5 more
wiley   +1 more source

Role of cyclophilin B in tumorigenesis and cisplatin resistance in hepatocellular carcinoma in humans [PDF]

Hepatology, 2011
Cyclophilin B (CypB) performs diverse roles in living cells, but its role in hepatocellular carcinoma (HCC) is largely unclear. To reveal its role in HCC, we investigated the induction of CypB under hypoxia and its functions in tumor cells in vitro and in vivo.
Yeonghwan, Kim, Miran, Jang, Sangbin, Lim, Hyeran, Won, Kyung-Sik, Yoon, Jae-Hoon, Park, Hyo Jong, Kim, Byung-Ho, Kim, Won-Sang, Park, Joohun, Ha, Sung-Soo, Kim   +10 more
openaire   +2 more sources

Cyclophilin sequence analysis.

, 2012
(A) Neighbor-joining tree of putative cyclophilin L. longipalpis (RAAPBAR022E08/AM092289, male reproductive organs and whole female cDNA libraries), A. gambiae (AGAP007088-PA), A. aegypti (AAEL013279), D.
Glauber Wagner (173002), Nataly A. Souza (138702), Rodolpho M. Albano (172995), Denise B. S. Dias (172981), Renata V. D. M. Azevedo (172978), Alberto M. R. Davila (173010), Camila J. Mazzoni (172989), Alexandre A. Peixoto (138715), Jorge A. C. Bretãs (172984)   +8 more
core   +1 more source